دورية أكاديمية
Clinical Predictors of Laryngeal Preservation Rate in Stage III-IV Laryngeal Cancer and Hypopharyngeal Cancer Patients Treated with Organ Preservation.
| العنوان: | Clinical Predictors of Laryngeal Preservation Rate in Stage III-IV Laryngeal Cancer and Hypopharyngeal Cancer Patients Treated with Organ Preservation. |
|---|---|
| المؤلفون: | Tangsriwong K; Department of Radiation Oncology, Rajavithi Hospital, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. Email: kanograt.nk@gmail.com, Jitreetat T; Department of Otolaryngology, Head and Neck Surgery, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. |
| المصدر: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2019 Jul 01; Vol. 20 (7), pp. 2051-2057. Date of Electronic Publication: 2019 Jul 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention, |
| مواضيع طبية MeSH: | Salvage Therapy*, Chemoradiotherapy/*mortality , Hypopharyngeal Neoplasms/*pathology , Laryngeal Neoplasms/*pathology , Organ Sparing Treatments/*mortality, Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Hypopharyngeal Neoplasms/therapy ; Laryngeal Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Staging ; Remission Induction ; Retrospective Studies ; Survival Rate ; Treatment Outcome |
| مستخلص: | Purpose: To determine factors affecting laryngeal preservation rate in laryngeal and hypopharyngeal cancer patients treated with organ preservation. Material and Methods: Retrospective study examining stage III to IV laryngeal and hypopharyngeal cancer patients who have been treated with organ preservation. Conventional radiation must be applied in all patients with minimum dose of 45 Gray. Weekly or triweekly chemotherapy can be adding during radiation. Salvage surgery should be considered in residual disease or local recurrence. Kaplan-Meier was used for survival analysis and, Log rank test and Cox proportional hazard test were used for uni and multivariate analysis. Results: From January 2010 to October 2014, there were 69 patients treated with laryngeal preservation and 53 patients received radiation dose 61-70 Gray. After completing radiation, we found that 44 patients have no residual tumor within 6 months and 33 patients can preserve their functional larynx later with complete response (median follow up 6 mo, range 0-46.3 mo). The 1-year, 2-year and 3-year laryngeal preservation rate was 49%, 36 % and 32 % respectively. On univariate analysis, lower nodal stage (p = 0.008), stage III disease (p = 0.046), tumor volume <10 ml (p = 0.005), no true vocal cord involvement (p = 0.016), dose 61-70 Gray (p < 0.001) and no interruption of treatment (p = 0.017) have better laryngeal preservation rates. ECOG performance status 2, higher nodal stage, stage IV, presence of true vocal cord involvement, upper airway obstruction before/during radiation and radiation dose below 61-70 Gray had an effect on worse overall survival when evaluated with univariate analysis statistical significance. Conclusion: For factors that affected laryngeal preservation in our study were nodal stage, group stage, tumor volume, true vocal cord involvement, radiation dose and treatment break time more than one week with statistical significance. |
| References: | Oral Oncol. 2011 Dec;47(12):1154-8. (PMID: 21873105) Int J Radiat Oncol Biol Phys. 2000 Apr 1;47(1):65-71. (PMID: 10758306) Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1823-30. (PMID: 21549516) Arch Otolaryngol Head Neck Surg. 2005 Sep;131(9):815-8. (PMID: 16172362) Ann Oncol. 2009 May;20(5):921-7. (PMID: 19179556) Am J Surg. 1997 Nov;174(5):518-22. (PMID: 9374228) Head Neck. 2008 Dec;30(12):1535-42. (PMID: 18704968) Laryngoscope. 2008 Feb;118(2):300-6. (PMID: 18030164) Eur Arch Otorhinolaryngol. 2009 Sep;266(9):1333-52. (PMID: 19597837) J Clin Oncol. 2008 Jul 20;26(21):3582-9. (PMID: 18559875) Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):398-402. (PMID: 19394155) Oncologist. 2010;15 Suppl 3:30-2. (PMID: 21036887) Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):594-601. (PMID: 26068492) Oncol Rep. 2009 Nov;22(5):1163-7. (PMID: 19787235) Arch Otolaryngol Head Neck Surg. 2009 Dec;135(12):1209-17. (PMID: 20026818) |
| فهرسة مساهمة: | Keywords: Hypopharyngeal cancer; Keywords:clinical predictor; laryngeal cancer; laryngeal preservation; survival outcomes |
| تواريخ الأحداث: | Date Created: 20190728 Date Completed: 20200106 Latest Revision: 20200106 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6745228 |
| DOI: | 10.31557/APJCP.2019.20.7.2051 |
| PMID: | 31350965 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2476-762X |
|---|---|
| DOI: | 10.31557/APJCP.2019.20.7.2051 |