دورية أكاديمية
أعرض في EDS

White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.

التفاصيل البيبلوغرافية
العنوان: White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
المؤلفون: Peters JM; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Struyven RR; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Prohl AK; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Vasung L; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Stajduhar A; Croatian Institute for Brain Research and Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, Zagreb, Croatia., Taquet M; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Bushman JJ; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Lidov H; Division of Neuropathology, Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Singh JM; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Scherrer B; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Madsen JR; Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Prabhu SP; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Sahin M; Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Afacan O; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Warfield SK; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
المصدر: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2019 Jul; Vol. 6 (7), pp. 1178-1190. Date of Electronic Publication: 2019 Jun 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Hoboken, NJ] : Wiley Periodicals, Inc on behalf of American Neurological Association, [2014]-
مواضيع طبية MeSH: Myelin Sheath/*pathology , Tuberous Sclerosis/*diagnostic imaging , Tuberous Sclerosis/*pathology , White Matter/*diagnostic imaging , White Matter/*pathology, Anisotropy ; Brain/pathology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Diffusion Tensor Imaging/methods ; Female ; Gliosis/pathology ; Humans ; Infant ; Infant, Newborn ; Male ; Neurons/pathology
مستخلص: Objective: Diffusion tensor imaging (DTI) of the white matter is a biomarker for neurological disease burden in tuberous sclerosis complex (TSC). To clarify the basis of abnormal diffusion in TSC, we correlated ex vivo high-resolution diffusion imaging with histopathology in four tissue types: cortex, tuber, perituber, and white matter.
Methods: Surgical specimens of three children with TSC were scanned in a 3T or 7T MRI with a structural image isotropic resolution of 137-300 micron, and diffusion image isotropic resolution of 270-1,000 micron. We stained for myelin (luxol fast blue, LFB), gliosis (glial fibrillary acidic protein, GFAP), and neurons (NeuN) and registered the digitized histopathology slides (0.686 micron resolution) to MRI for visual comparison. We then performed colocalization analysis in four tissue types in each specimen. Finally, we applied a linear mixed model (LMM) for pooled analysis across the three specimens.
Results: In white matter and perituber regions, LFB optical density measures correlated with fractional anisotropy (FA) and inversely with mean diffusivity (MD). In white matter only, GFAP correlated with MD, and inversely with FA. In tubers and in the cortex, there was little variation in mean LFB and GFAP signal intensity, and no correlation with MRI metrics. Neuronal density correlated with MD. In the analysis of the combined specimens, the most robust correlation was between white matter MD and LFB metrics.
Interpretation: In TSC, diffusion imaging abnormalities in microscopic tissue types correspond to specific histopathological markers. Across all specimens, white matter diffusivity correlates with myelination.
(© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.)
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معلومات مُعتمدة: U01 NS082320 United States NS NINDS NIH HHS; International NICHD; International NIMH; W81XWH-11-1-0365 International U.S. Department of Defense; U54 NS092090 United States NS NINDS NIH HHS; U54 HD090255 United States NS NINDS NIH HHS; P30 NS072030 United States NS NINDS NIH HHS; U54 HD090255 United States HD NICHD NIH HHS; UL1 TR001102 United States TR NCATS NIH HHS; R01 NS079788 United States NS NINDS NIH HHS; UL1 TR001102 United States NS NINDS NIH HHS; International NCATS
تواريخ الأحداث: Date Created: 20190730 Date Completed: 20200513 Latest Revision: 20200513
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6649396
DOI: 10.1002/acn3.793
PMID: 31353853
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-9503
DOI:10.1002/acn3.793