دورية أكاديمية
أعرض في EDS

Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease.

التفاصيل البيبلوغرافية
العنوان: Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease.
المؤلفون: Garofallo SB; Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil., Portal VL; Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil., Markoski MM; Graduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Street, 245, Porto Alegre, Rio Grande do Sul 90050-170, Brazil., Dias LD; Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil., de Quadrosa AS; Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil., Marcadenti A; Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.; Graduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Street, 245, Porto Alegre, Rio Grande do Sul 90050-170, Brazil.; Institute of Research,Coracao Hospital (HCor), Abílio Soares Street, 250, São Paulo, São Paulo 04004-05, Brazil.
المصدر: Journal of obesity [J Obes] 2019 Jul 03; Vol. 2019, pp. 3139278. Date of Electronic Publication: 2019 Jul 03 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101526295 Publication Model: eCollection Cited Medium: Internet ISSN: 2090-0716 (Electronic) Linking ISSN: 20900708 NLM ISO Abbreviation: J Obes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York ; Cairo, Egypt : Hindawi Publishing Corporation, 2010-
مواضيع طبية MeSH: Coronary Artery Disease/*blood , Inflammation/*blood , Monocytes/*physiology , Obesity/*physiopathology, Adiposity ; Anthropometry ; Biomarkers/blood ; Body Mass Index ; Coronary Artery Disease/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Inflammation/physiopathology ; Male ; Middle Aged ; Monocytes/classification ; Obesity/blood ; Obesity/complications
مستخلص: Background: Recruitment of monocytes and low-grade inflammation process are both involved in obesity and in atherosclerosis. Thus, the aim of this study was to evaluate the correlation among indicators of adiposity, monocyte subtypes, and inflammatory markers in patients with stable coronary artery disease (CAD).
Methods: This was a cross-sectional study including 97 patients with stable CAD aged >40 years. Traditional anthropometric indicators of adiposity (body mass index (BMI); waist, hip, and neck circumferences; and waist-hip ratio) and nontraditional anthropometric indicators of adiposity (lipid accumulation product index (LAP), visceral adiposity index (VAI), and deep-abdominal-adipose-tissue index (DAAT)) were determined. Immunoprecipitation, turbidimetry, coagulometric method, and CBA were used for the evaluation of inflammatory markers (hs-CRP, IL-2, IL-4, IL-6, IL-10, and INF- γ ). Monocyte subtypes were identified by flow cytometry and defined as CD14++ CD16- (Mon1), CD14++ CD16+ (Mon2), and CD14+ CD16++ (Mon3). Pearson's correlation coefficient and adjusted partial correlation were calculated.
Results: Monocyte subtypes were correlated with inflammation regardless of nutritional status according to BMI. In overweight individuals, LAP was correlated with IL-4 and fibrinogen ( P < 0.01 and P < 0.05, respectively) and VAI with IL-4 ( P < 0.05). In obese patients, the BMI, waist, neck, and hip circumferences, and DAAT were correlated with IL-6 ( P < 0.05), regardless of age and sex. The hip circumference was correlated positively with Mon1 ( r  = 0.40, P = 0.007) and negatively with Mon3 ( r  = -0.35, P = 0.02) in obese subjects.
Conclusion: Monocyte subtypes are correlated with inflammation in patients with stable CAD independently of BMI, whereas traditional and nontraditional indicators of adiposity are correlated differently with inflammatory markers and monocytes, according to the nutritional status.
References: Immunology. 1999 Apr;96(4):529-36. (PMID: 10233738)
Atherosclerosis. 1999 May;144(1):251-61. (PMID: 10381298)
Hypertension. 2001 Feb;37(2 Pt 2):587-93. (PMID: 11230339)
Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):456-61. (PMID: 11884290)
Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. (PMID: 12900694)
Obes Res. 2004 Mar;12(3):482-7. (PMID: 15044665)
Clin Immunol. 2004 Mar;110(3):252-66. (PMID: 15047203)
Am Heart J. 2005 Jan;149(1):54-60. (PMID: 15660034)
BMC Cardiovasc Disord. 2005 Sep 08;5:26. (PMID: 16150143)
Eur J Clin Nutr. 2006 May;60(5):658-66. (PMID: 16391572)
J Clin Invest. 2007 Jan;117(1):195-205. (PMID: 17200719)
Am J Transplant. 2008 Jan;8(1):103-10. (PMID: 18021284)
J Leukoc Biol. 2008 Nov;84(5):1271-8. (PMID: 18664531)
Nat Rev Cardiol. 2009 Jun;6(6):399-409. (PMID: 19399028)
J Exp Med. 1991 Nov 1;174(5):1209-20. (PMID: 1940799)
Eur J Clin Nutr. 2010 Jan;64(1):16-22. (PMID: 19654593)
Eur Heart J. 2010 Feb;31(3):369-76. (PMID: 19687164)
Nat Rev Cardiol. 2010 Feb;7(2):77-86. (PMID: 20065951)
Diabetes Care. 2010 Apr;33(4):920-2. (PMID: 20067971)
Obesity (Silver Spring). 2010 May;18(5):879-83. (PMID: 20186138)
Thromb Haemost. 2010 Aug;104(2):412-4. (PMID: 20431842)
J Clin Endocrinol Metab. 2010 Aug;95(8):3701-10. (PMID: 20484490)
Obes Rev. 2011 Jun;12(6):478-81. (PMID: 20663064)
J Thromb Haemost. 2011 May;9(5):1056-66. (PMID: 21342432)
Br J Nutr. 2011 Dec;106 Suppl 3:S5-78. (PMID: 22133051)
J Am Coll Cardiol. 2012 Oct 16;60(16):1512-20. (PMID: 22999728)
Obes Rev. 2013 Jan;14(1):86-94. (PMID: 23072327)
J Nutr Biochem. 2013 Dec;24(12):2003-15. (PMID: 24120291)
Atherosclerosis. 2014 May;234(1):4-10. (PMID: 24583499)
Am J Clin Nutr. 2014 Nov;100(5):1244-51. (PMID: 25332322)
Curr Diabetes Rev. 2017;13(1):11-18. (PMID: 26467189)
J Pediatr Endocrinol Metab. 2016 Mar;29(3):289-96. (PMID: 26565545)
Kidney Res Clin Pract. 2013 Dec;32(4):147-52. (PMID: 26877933)
Ann Med. 2016 Sep;48(6):410-416. (PMID: 27181508)
Thromb Haemost. 2016 Sep 27;116(4):626-37. (PMID: 27412877)
Atherosclerosis. 2016 Oct;253:281-344. (PMID: 27594540)
Trials. 2016 Sep 05;17(1):437. (PMID: 27596284)
Rev Esp Cardiol (Engl Ed). 2017 May;70(5):331-337. (PMID: 27765543)
Arq Bras Cardiol. 2016 Sep;107(3 Suppl 3):7-13. (PMID: 27819381)
Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24. (PMID: 27979889)
MMWR Morb Mortal Wkly Rep. 2017 Jan 06;65(52):1457-1464. (PMID: 28056007)
J Clin Invest. 1997 Jun 1;99(11):2752-61. (PMID: 9169506)
J Intern Med. 1997 Nov;242(5):401-6. (PMID: 9408070)
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20190730 Date Completed: 20200810 Latest Revision: 20200810
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6637687
DOI: 10.1155/2019/3139278
PMID: 31354986
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-0716
DOI:10.1155/2019/3139278