تقرير
Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia.
| العنوان: | Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia. |
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| المؤلفون: | Chai KY; Department of Haematology, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand., Quijano CJ; Department of Haematology, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand., Chiruka S; Department of Haematology, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand. |
| المصدر: | Case reports in hematology [Case Rep Hematol] 2019 Jul 01; Vol. 2019, pp. 4684156. Date of Electronic Publication: 2019 Jul 01 (Print Publication: 2019). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101576456 Publication Model: eCollection Cited Medium: Print ISSN: 2090-6560 (Print) Linking ISSN: 20906579 NLM ISO Abbreviation: Case Rep Hematol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Pub. Corp. |
| مستخلص: | Diamond-Blackfan anaemia (DBA) is a rare congenital red cell aplasia that presents in infancy. The exact molecular mechanism of ineffective erythropoiesis and red cell aplasia remains unclear, rendering targeted therapy elusive. The mainstay treatment of DBA is with regular blood transfusion and long-term corticosteroids, both of which have long-term side effects. We report a case of DBA successfully treated with danazol, a synthetic androgen, and suggest that danazol be considered as a viable option in patients who become refractory to steroids and are considered high risk or unfit for allogeneic stem cell transplantation. |
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| تواريخ الأحداث: | Date Created: 20190730 Latest Revision: 20200930 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6636591 |
| DOI: | 10.1155/2019/4684156 |
| PMID: | 31355022 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2090-6560 |
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| DOI: | 10.1155/2019/4684156 |