دورية أكاديمية
أعرض في EDS

Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.

التفاصيل البيبلوغرافية
العنوان: Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.
المؤلفون: Donovan LJ; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Spencer WC; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Kitt MM; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Eastman BA; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Lobur KJ; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Jiao K; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Silver J; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States., Deneris ES; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
المصدر: ELife [Elife] 2019 Jul 29; Vol. 8. Date of Electronic Publication: 2019 Jul 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Axons/*physiology , LIM-Homeodomain Proteins/*metabolism , Serotonergic Neurons/*physiology , Transcription Factors/*metabolism, Animals ; Gene Expression Profiling ; LIM-Homeodomain Proteins/deficiency ; Mice ; Prosencephalon/cytology ; Spinal Cord/cytology ; Transcription Factors/deficiency
مستخلص: Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question by studying the formation of mouse serotonin (5-HT) axons, the exemplar of long-range profusely arborized axon architectures. We report that LIM homeodomain factor 1b (Lmx1b)-deficient 5-HT neurons fail to generate axonal projections to the forebrain and spinal cord. Stage-specific targeting demonstrates that Lmx1b is required at successive stages to control 5-HT axon primary outgrowth, selective routing, and terminal arborization. We show a Lmx1b→Pet1 regulatory cascade is temporally required for 5-HT arborization and upregulation of the 5-HT axon arborization gene, Protocadherin-alphac2, during postnatal development of forebrain 5-HT axons. Our findings identify a temporal regulatory mechanism in which a single continuously expressed transcription factor functions at successive stages to orchestrate the progressive development of long-range axon architectures enabling expansive neuromodulation.
Competing Interests: LD, WS, MK, BE, KL, KJ, JS, ED No competing interests declared
(© 2019, Donovan et al.)
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معلومات مُعتمدة: P50 MH096972 United States MH NIMH NIH HHS; R01 MH062723 United States MH NIMH NIH HHS; P50 MH078028 United States MH NIMH NIH HHS; RO1 MH062723 United States MH NIMH NIH HHS; T32 GM008056 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Lmx1b; arborization; axons; development; developmental biology; mouse; neuroscience; serotonin; transcription factor
سلسلة جزيئية: GEO GSE130514; GSE74315
المشرفين على المادة: 0 (LIM homeobox transcription factor 1 beta)
0 (LIM-Homeodomain Proteins)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20190730 Date Completed: 20200203 Latest Revision: 20240419
رمز التحديث: 20240419
مُعرف محوري في PubMed: PMC6685705
DOI: 10.7554/eLife.48788
PMID: 31355748
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.48788