دورية أكاديمية
أعرض في EDS

Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.

التفاصيل البيبلوغرافية
العنوان: Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.
المؤلفون: Lind AL; Gladstone Institutes, San Francisco, CA, USA., Lai YYY; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Mostovoy Y; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Holloway AK; Gladstone Institutes, San Francisco, CA, USA., Iannucci A; Department of Biology, University of Florence, Sesto Fiorentino, Italy., Mak ACY; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Fondi M; Department of Biology, University of Florence, Sesto Fiorentino, Italy., Orlandini V; Department of Biology, University of Florence, Sesto Fiorentino, Italy., Eckalbar WL; Institute for Human Genetics, University of California, San Francisco, CA, USA., Milan M; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy., Rovatsos M; Department of Ecology, Charles University, Prague, Czech Republic.; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Liběchov, Czech Republic., Kichigin IG; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia., Makunin AI; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia., Johnson Pokorná M; Department of Ecology, Charles University, Prague, Czech Republic.; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Liběchov, Czech Republic., Altmanová M; Department of Ecology, Charles University, Prague, Czech Republic.; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Liběchov, Czech Republic., Trifonov VA; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia., Schijlen E; B.U. Bioscience, Wageningen University, Wageningen, The Netherlands., Kratochvíl L; Department of Ecology, Charles University, Prague, Czech Republic., Fani R; Department of Biology, University of Florence, Sesto Fiorentino, Italy., Velenský P; Prague Zoological Garden, Prague, Czech Republic., Rehák I; Prague Zoological Garden, Prague, Czech Republic., Patarnello T; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy., Jessop TS; Centre for Integrative Ecology, Deakin University, Waurn Ponds, Victoria, Australia., Hicks JW; Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine, CA, USA., Ryder OA; Institute for Conservation Research, San Diego Zoo, Escondido, CA, USA., Mendelson JR 3rd; Zoo Atlanta, Atlanta, GA, USA.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Ciofi C; Department of Biology, University of Florence, Sesto Fiorentino, Italy., Kwok PY; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA.; Department of Dermatology, University of California, San Francisco, CA, USA., Pollard KS; Gladstone Institutes, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu.; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu.; Institute for Computational Health Sciences, University of California, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu.; Chan-Zuckerberg BioHub, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu., Bruneau BG; Gladstone Institutes, San Francisco, CA, USA. benoit.bruneau@gladstone.ucsf.edu.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA. benoit.bruneau@gladstone.ucsf.edu.; Department of Pediatrics, University of California, San Francisco, CA, USA. benoit.bruneau@gladstone.ucsf.edu.
المصدر: Nature ecology & evolution [Nat Ecol Evol] 2019 Aug; Vol. 3 (8), pp. 1241-1252. Date of Electronic Publication: 2019 Jul 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101698577 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-334X (Electronic) Linking ISSN: 2397334X NLM ISO Abbreviation: Nat Ecol Evol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Springer Nature
مواضيع طبية MeSH: Cardiovascular System* , Lizards*, Acclimatization ; Animals ; Chromosomes
مستخلص: Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.
التعليقات: Comment in: Nat Rev Genet. 2019 Oct;20(10):564-565. (PMID: 31388141)
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معلومات مُعتمدة: UM1 HL098179 United States HL NHLBI NIH HHS; U01 HL131003 United States HL NHLBI NIH HHS; T32 HL007731 United States HL NHLBI NIH HHS; T32 AR007175 United States AR NIAMS NIH HHS; R01 HG005946 United States HG NHGRI NIH HHS
تواريخ الأحداث: Date Created: 20190731 Date Completed: 20191028 Latest Revision: 20231013
رمز التحديث: 20231013
مُعرف محوري في PubMed: PMC6668926
DOI: 10.1038/s41559-019-0945-8
PMID: 31358948
قاعدة البيانات: MEDLINE
الوصف
تدمد:2397-334X
DOI:10.1038/s41559-019-0945-8