دورية أكاديمية
Effect of caloric restriction and rapamycin on ovarian aging in mice.
العنوان: | Effect of caloric restriction and rapamycin on ovarian aging in mice. |
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المؤلفون: | Garcia DN; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Saccon TD; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Pradiee J; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Rincón JAA; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Andrade KRS; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Rovani MT; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Mondadori RG; Instituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Cruz LAX; Instituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Barros CC; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Masternak MM; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.; Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznan, Poland., Bartke A; Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL, USA., Mason JB; Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA., Schneider A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil. |
المصدر: | GeroScience [Geroscience] 2019 Aug; Vol. 41 (4), pp. 395-408. Date of Electronic Publication: 2019 Jul 29. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cham : Springer International Publishing, [2017]- |
مواضيع طبية MeSH: | Caloric Restriction* , Ovarian Reserve*, Immunosuppressive Agents/*pharmacology , Ovarian Follicle/*pathology , Sirolimus/*pharmacology, Animals ; Body Weight ; Female ; Forkhead Box Protein O3/genetics ; Forkhead Box Protein O3/metabolism ; Gene Expression ; Insulin Resistance ; Mice, Inbred C57BL ; Ovary/metabolism ; RNA/metabolism |
مستخلص: | Caloric restriction (CR) increases the preservation of the ovarian primordial follicular reserve, which can potentially delay menopause. Rapamycin also increases preservation on the ovarian reserve, with similar mechanism to CR. Therefore, the aim of our study was to evaluate the effects of rapamycin and CR on metabolism, ovarian reserve, and gene expression in mice. Thirty-six female mice were allocated into three groups: control, rapamycin-treated (4 mg/kg body weight every other day), and 30% CR. Caloric restricted females had lower body weight (P < 0.05) and increased insulin sensitivity (P = 0.003), while rapamycin injection did not change body weight (P > 0.05) and induced insulin resistance (P < 0.05). Both CR and rapamycin females displayed a higher number of primordial follicles (P = 0.02 and 0.04, respectively), fewer primary, secondary, and tertiary follicles (P < 0.05) and displayed increased ovarian Foxo3a gene expression (P < 0.05). Despite the divergent metabolic effects of the CR and rapamycin treatments, females from both groups displayed a similar increase in ovarian reserve, which was associated with higher expression of ovarian Foxo3a. |
References: | Biol Reprod. 1979 May;20(4):773-8. (PMID: 454765) Dev Biol. 2006 Nov 1;299(1):1-11. (PMID: 16970938) Aging Cell. 2008 Jun;7(3):285-90. (PMID: 18346217) J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1238-45. (PMID: 16282554) Front Genet. 2015 Jul 22;6:247. (PMID: 26257774) Trends Endocrinol Metab. 2009 Sep;20(7):325-31. (PMID: 19713122) Age (Dordr). 2014;36(4):9701. (PMID: 25099774) Curr Biol. 2014 Nov 3;24(21):2501-8. (PMID: 25438940) Geroscience. 2017 Feb;39(1):51-59. (PMID: 28299640) Curr Top Dev Biol. 2004;63:189-225. (PMID: 15536017) Mol Cell Endocrinol. 1998 Oct 25;145(1-2):67-73. (PMID: 9922101) Fertil Steril. 2011 Dec;96(6):1357-61. (PMID: 22014879) Mol Cell Endocrinol. 2017 Jan 5;439:328-336. (PMID: 27663076) Metabolism. 2014 Jan;63(1):94-103. (PMID: 24135502) PLoS One. 2012;7(7):e40573. (PMID: 22829877) Geroscience. 2017 Aug;39(4):457-463. (PMID: 28889220) Gene. 2013 Jul 1;523(1):82-7. (PMID: 23566837) Reproduction. 2004 May;127(5):569-80. (PMID: 15129012) Nutr Res Rev. 2015 Dec;28(2):100-120. (PMID: 26391585) Geroscience. 2019 Feb;41(1):25-38. (PMID: 30547325) Aging Cell. 2017 Aug;16(4):825-836. (PMID: 28544226) Aging (Albany NY). 2014 Oct;6(10):900-12. (PMID: 25411241) Br J Pharmacol. 2012 Apr;165(7):2325-40. (PMID: 22014210) Mol Cell Endocrinol. 2017 Nov 5;455:23-32. (PMID: 27771355) Endocrinology. 2005 Sep;146(9):3718-23. (PMID: 15919742) Arq Bras Endocrinol Metabol. 2009 Jul;53(5):667-72. (PMID: 19768257) Hum Reprod Update. 2015 Nov-Dec;21(6):779-86. (PMID: 26231759) Cell Cycle. 2010 Feb 15;9(4):683-8. (PMID: 20139716) Sci Transl Med. 2013 May 15;5(185):185ra62. (PMID: 23677591) Hum Mol Genet. 2010 Feb 1;19(3):397-410. (PMID: 19843540) Science. 2003 Jul 11;301(5630):215-8. (PMID: 12855809) Zhonghua Fu Chan Ke Za Zhi. 2013 Oct;48(10):745-9. (PMID: 24406130) Reprod Sci. 2015 Jan;22(1):60-7. (PMID: 25001019) Proc R Soc Lond B Biol Sci. 1963 Oct 22;158:417-33. (PMID: 14070052) Acta Endocrinol (Copenh). 1969 Sep;62(1):98-116. (PMID: 5394354) Aging Cell. 2012 Aug;11(4):675-82. (PMID: 22587563) Cell Metab. 2013 Mar 5;17(3):456-62. (PMID: 23473038) Biol Reprod. 2016 Apr;94(4):76. (PMID: 26911429) Endocr Rev. 2009 Aug;30(5):465-93. (PMID: 19589949) J Ovarian Res. 2014 Dec 29;7:120. (PMID: 25543533) Mol Cell. 2006 Apr 21;22(2):159-68. (PMID: 16603397) Diabetes. 2012 Jun;61(6):1315-22. (PMID: 22618766) Genes Dev. 2006 Jan 15;20(2):174-84. (PMID: 16418483) Geroscience. 2017 Apr;39(2):117-127. (PMID: 28374166) Gen Comp Endocrinol. 2011 Nov 1;174(2):232-7. (PMID: 21945120) PLoS One. 2015 Feb 24;10(2):e0117769. (PMID: 25710488) Dev Biol. 2008 Sep 1;321(1):197-204. (PMID: 18601916) Geroscience. 2018 Jun 21;:. (PMID: 29931650) Age (Dordr). 2016 Dec;38(5-6):513-523. (PMID: 27629107) Ginekol Pol. 2008 Feb;79(2):137-40. (PMID: 18510094) Dev Biol. 1997 Apr 1;184(1):122-37. (PMID: 9142989) Aging Cell. 2008 Oct;7(5):622-9. (PMID: 18549458) Neurosci Res. 2009 Jul;64(3):330-4. (PMID: 19376166) Hum Reprod Update. 2014 Sep-Oct;20(5):688-701. (PMID: 24821925) Cell. 2006 Feb 10;124(3):471-84. (PMID: 16469695) |
معلومات مُعتمدة: | R03 AG059846 United States AG NIA NIH HHS; R15 AG059190 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: FOXO3a; Ovarian reserve; Rapamycin; mTOR |
المشرفين على المادة: | 0 (Forkhead Box Protein O3) 0 (FoxO3 protein, mouse) 0 (Immunosuppressive Agents) 63231-63-0 (RNA) W36ZG6FT64 (Sirolimus) |
تواريخ الأحداث: | Date Created: 20190731 Date Completed: 20200512 Latest Revision: 20240721 |
رمز التحديث: | 20240721 |
مُعرف محوري في PubMed: | PMC6815295 |
DOI: | 10.1007/s11357-019-00087-x |
PMID: | 31359237 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2509-2723 |
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DOI: | 10.1007/s11357-019-00087-x |