دورية أكاديمية
أعرض في EDS

Effect of caloric restriction and rapamycin on ovarian aging in mice.

التفاصيل البيبلوغرافية
العنوان: Effect of caloric restriction and rapamycin on ovarian aging in mice.
المؤلفون: Garcia DN; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Saccon TD; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Pradiee J; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Rincón JAA; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Andrade KRS; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Rovani MT; Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Mondadori RG; Instituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Cruz LAX; Instituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Barros CC; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Masternak MM; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.; Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznan, Poland., Bartke A; Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL, USA., Mason JB; Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA., Schneider A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
المصدر: GeroScience [Geroscience] 2019 Aug; Vol. 41 (4), pp. 395-408. Date of Electronic Publication: 2019 Jul 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Caloric Restriction* , Ovarian Reserve*, Immunosuppressive Agents/*pharmacology , Ovarian Follicle/*pathology , Sirolimus/*pharmacology, Animals ; Body Weight ; Female ; Forkhead Box Protein O3/genetics ; Forkhead Box Protein O3/metabolism ; Gene Expression ; Insulin Resistance ; Mice, Inbred C57BL ; Ovary/metabolism ; RNA/metabolism
مستخلص: Caloric restriction (CR) increases the preservation of the ovarian primordial follicular reserve, which can potentially delay menopause. Rapamycin also increases preservation on the ovarian reserve, with similar mechanism to CR. Therefore, the aim of our study was to evaluate the effects of rapamycin and CR on metabolism, ovarian reserve, and gene expression in mice. Thirty-six female mice were allocated into three groups: control, rapamycin-treated (4 mg/kg body weight every other day), and 30% CR. Caloric restricted females had lower body weight (P < 0.05) and increased insulin sensitivity (P = 0.003), while rapamycin injection did not change body weight (P > 0.05) and induced insulin resistance (P < 0.05). Both CR and rapamycin females displayed a higher number of primordial follicles (P = 0.02 and 0.04, respectively), fewer primary, secondary, and tertiary follicles (P < 0.05) and displayed increased ovarian Foxo3a gene expression (P < 0.05). Despite the divergent metabolic effects of the CR and rapamycin treatments, females from both groups displayed a similar increase in ovarian reserve, which was associated with higher expression of ovarian Foxo3a.
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معلومات مُعتمدة: R03 AG059846 United States AG NIA NIH HHS; R15 AG059190 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: FOXO3a; Ovarian reserve; Rapamycin; mTOR
المشرفين على المادة: 0 (Forkhead Box Protein O3)
0 (FoxO3 protein, mouse)
0 (Immunosuppressive Agents)
63231-63-0 (RNA)
W36ZG6FT64 (Sirolimus)
تواريخ الأحداث: Date Created: 20190731 Date Completed: 20200512 Latest Revision: 20240721
رمز التحديث: 20240721
مُعرف محوري في PubMed: PMC6815295
DOI: 10.1007/s11357-019-00087-x
PMID: 31359237
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-019-00087-x