دورية أكاديمية
Oncogenic Human Papillomavirus involvement in epithelial ovarian carcinoma among women in Morocco.
| العنوان: | Oncogenic Human Papillomavirus involvement in epithelial ovarian carcinoma among women in Morocco. |
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| المؤلفون: | Hammou RA; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco., Benhessou M; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco.; Universite Mohamed VI des Sciences de la sante of Casablanca, Morocco.; Faculty of Medicine and Pharmacy of Casablanca,University Hassan II of Casablanca, Morocco., Bouziyane A; Universite Mohamed VI des Sciences de la sante of Casablanca, Morocco., Hassou N; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco., Benhchekroun MN; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco., Bessi H; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco., Ennaji MM; Laboratory of Virology,Microbiology, Quality and Biotechnologies/Eco-toxicology and biodiversity,faculty of Sciences and Techniques, Mohammedia,University Hassan II of Casablanca,BP:146 Mohammedia 20650, Morocco. |
| المصدر: | Bioinformation [Bioinformation] 2019 Feb 03; Vol. 15 (1), pp. 55-60. Date of Electronic Publication: 2019 Feb 03 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Biomedical Informatics Pub. Group Country of Publication: Singapore NLM ID: 101258255 Publication Model: eCollection Cited Medium: Print ISSN: 0973-2063 (Print) Linking ISSN: 09732063 NLM ISO Abbreviation: Bioinformation Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Singapore] : Biomedical Informatics Pub. Group, 2005- |
| مستخلص: | Epithelial Ovarian cancer (EOC) although rare is the most lethal gynecological cancer in women worldwide. Despite its high prevalence few studies have been performed to evaluate the prevalence and determinants of HPV infection worldwide. The aim of the present study was to investigate the presence of HPV-DNA in Moroccan patients with EOC using PCR among women in Casablanca, and to examine the prevalence of some HPV genotypes in Moroccan population. We performed a study of HPV detection on Fresh biopsies of 70 epithelial ovarian cancer patients. PCR was realized using the MY09/11 and GP5+/6+ primers. Genotyping of HPV was performed by PCR typespecific for HPV 6, 11, 16, 18, 31, and 33.Data was statistically analyzed using SPSS software. Hence, the mean age was 48.9 years (range,21-76 years). Serous adeno carcinoma (75.71%) and stage III of the disease represent the majority of cases. eight patients were HPV positive (11.42%).Results of HPV genotyping revealed predominance of two genotypes: HPV 16 (87.5%) and HPV 31(12.5).No co-infection identified. Approximately 75% of positive cases had a serous cystadeno carcinoma and more than 62,5% had FIGO advanced stage (III or IV).Our study showed that high-risk HPV infection could play a major role among patients with EOC in Morocco. |
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| فهرسة مساهمة: | Keywords: Genotyping; Oncogenic Human Papillomavirus; PCR typespecific; epithelial ovarian carcinoma; fresh biopsies; viral carcinogenesis |
| تواريخ الأحداث: | Date Created: 20190731 Latest Revision: 20240718 |
| رمز التحديث: | 20240718 |
| مُعرف محوري في PubMed: | PMC6651035 |
| DOI: | 10.6026/97320630015055 |
| PMID: | 31360000 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0973-2063 |
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| DOI: | 10.6026/97320630015055 |