دورية أكاديمية
أعرض في EDS

Ten Year Review of Pulmonary Nocardiosis: A Series of 55 Cases.

التفاصيل البيبلوغرافية
العنوان: Ten Year Review of Pulmonary Nocardiosis: A Series of 55 Cases.
المؤلفون: Zia K; Internal Medicine, Liaquat College of Medicine and Dentistry, Karachi, PAK., Nafees T; Internal Medicine, Karachi Medical and Dental College, Karachi, PAK., Faizan M; Internal Medicine, Dow University of Health Sciences, Karachi, PAK., Salam O; Internal Medicine, Dow University of Health Sciences, Karachi, PAK., Asad SI; Internal Medicine, Dow University of Health Sciences, Karachi, PAK., Khan YA; Miscellaneous, Dow University of Health Sciences, Karachi, PAK., Altaf A; Internal Medicine, Dr. Ziauddin Hospital, Karachi, PAK.
المصدر: Cureus [Cureus] 2019 May 26; Vol. 11 (5), pp. e4759. Date of Electronic Publication: 2019 May 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: Electronic Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Introduction Nocardiosis is a rare opportunistic bacterial infection usually seen in immunosuppressed patients. It is caused by gram-positive, aerobic actinomycetes of the Nocardia genus. The most common site of infection is lungs; but it may affect other organs or even disseminate into blood. Methods In this a 10-year retrospective review, all diagnosed cases of Pulmonary Nocardiosis in a tertiary care hospital were included. The clinical and radiological characteristics, course of complications and lifesaving interventions, and disease outcome were evaluated. Results Among the 55 identified cases, most common risk factor was chronic steroid therapy (n=38; 69.1%). Among respiratory diseases, chronic obstructive pulmonary disease (n=13; 23.6%) and tuberculosis (n=12; 21.8%) were the most common. On chest radiograph, pleural effusion (n=23; 41.8%) and consolidation (n=22; 40.0%) were the common findings. Complications were observed in 32 (58.2%) patients with septicemia and respiratory failure being the most common (n=15; 46.8% in each). Dissemination occurred in 10 (31.2%) patients. The mortality rate of Nocardia is 34.5% (n=19). Conclusion The disease burden of Nocardia is underestimated by clinicians and researchers. Pulmonary Nocardia should always be a differential diagnosis of signs of lower respiratory tract infection and must be excluded in patients not responding to treatment of chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis. Early recognition and individualized management plan can ensure successful recovery.
Competing Interests: The authors have declared that no competing interests exist.
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فهرسة مساهمة: Keywords: case series; chronic steroid therapy; hiv; nocardiosis; pakistan; pulmonary infections; pulmonary nocardia; rare infection
تواريخ الأحداث: Date Created: 20190801 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6663111
DOI: 10.7759/cureus.4759
PMID: 31363440
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.4759