التفاصيل البيبلوغرافية
| العنوان: |
Fetal surgery for spina bifida. |
| المؤلفون: |
Dewan MC, Wellons JC |
| المصدر: |
Journal of neurosurgery. Pediatrics [J Neurosurg Pediatr] 2019 Aug 01; Vol. 24 (2), pp. 105-114. Date of Electronic Publication: 2019 Aug 01. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 101463759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-0715 (Electronic) Linking ISSN: 19330707 NLM ISO Abbreviation: J Neurosurg Pediatr Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Charlottesville, VA : American Association of Neurological Surgeons, 2004- |
| مواضيع طبية MeSH: |
Wound Closure Techniques*, Fetoscopy/*methods , Meningomyelocele/*surgery , Spinal Dysraphism/*surgery, Adolescent ; Adolescent Development ; Animals ; Cerebrospinal Fluid Shunts ; Child ; Child Development ; Cysts/etiology ; Disease Models, Animal ; Fetoscopy/adverse effects ; Humans ; Hydrocephalus/therapy ; Infant, Newborn ; Infant, Premature ; Medical Illustration ; Multicenter Studies as Topic ; Neural Tube Defects/etiology ; Patient Positioning ; Photography ; Postoperative Complications ; Quality of Life ; Randomized Controlled Trials as Topic ; Spinal Dysraphism/complications ; Treatment Outcome |
| مستخلص: |
The two-hit hypothesis of neural injury in the wake of open neural tube defects suggests an opportunity for preservation of function and potential reversibility of early morphological changes in the fetus diagnosed with myelomeningocele. The Management of Myelomeningocele Study (MOMS) demonstrated reduced need for shunting and improved neurological function in patients treated in utero relative to postnatally, thereby offering level 1 evidence supporting fetal repair. Subsequent studies have offered additional information about urological, orthopedic, radiological, and maternal factors surrounding fetal repair. The quest for robust long-term neurocognitive and motor function data is underway and poised to shape the future of fetal repair. In addition, technical innovations such as fetoscopic surgery aim to minimize maternal morbidity while conferring the beneficial effects observed with open intrauterine intervention. |
| فهرسة مساهمة: |
Keywords: CHOP = Children’s Hospital of Philadelphia; CM-II = Chiari malformation type II; CPC = choroid plexus cauterization; ETV = endoscopic third ventriculostomy; IUR = intrauterine repair; MM = myelomeningocele; MOMS = Management of Myelomeningocele Study; PROM = premature rupture of membranes; TCS = tethered cord syndrome; VP = ventriculoperitoneal; congenital; fMMR = fetal MM repair; fetal; fetoscopic; intrauterine; myelomeningocele; spina bifida |
| تواريخ الأحداث: |
Date Created: 20190802 Date Completed: 20200611 Latest Revision: 20210125 |
| رمز التحديث: |
20231215 |
| DOI: |
10.3171/2019.4.PEDS18383 |
| PMID: |
31370010 |
| قاعدة البيانات: |
MEDLINE |
