دورية أكاديمية
أعرض في EDS

Transcriptome analyses of cells carrying the Type II Csp231I restriction-modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor.

التفاصيل البيبلوغرافية
العنوان: Transcriptome analyses of cells carrying the Type II Csp231I restriction-modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor.
المؤلفون: Negri A; Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, Gdansk 80-308, Poland., Jąkalski M; Department of Plant Taxonomy and Nature Conservation, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland., Szczuka A; Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, Gdansk 80-308, Poland., Pryszcz LP; Laboratory of Zebrafish Developmental Genomics, International Institute of Molecular and Cell Biology, Warsaw, ul. Trojdena 4, 02-109 Warsaw, Poland., Mruk I; Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, Gdansk 80-308, Poland.
المصدر: Nucleic acids research [Nucleic Acids Res] 2019 Oct 10; Vol. 47 (18), pp. 9542-9556.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Bacteriophages/*genetics , DNA Restriction-Modification Enzymes/*genetics , Escherichia coli/*genetics , Host-Pathogen Interactions/*genetics, Amino Acid Sequence/genetics ; Bacteriophages/pathogenicity ; Citrobacter/genetics ; DNA Restriction Enzymes/genetics ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Deoxyribonucleases, Type II Site-Specific/genetics ; Escherichia coli/virology ; Gene Expression Profiling/methods ; Gene Expression Regulation, Bacterial ; Gene Transfer, Horizontal/genetics ; Phenotype ; Transcription Factors/genetics ; Viral Proteins/genetics
مستخلص: Restriction-modification (R-M) systems represent an effective mechanism of defence against invading bacteriophages, and are widely spread among bacteria and archaea. In acquiring a Type II R-M system via horizontal gene transfer, the new hosts become more resistant to phage infection, through the action of a restriction endonuclease (REase), which recognizes and cleaves specific target DNAs. To protect the host cell's DNA, there is also a methyltransferase (MTase), which prevents DNA cleavage by the cognate REase. In some R-M systems, the host also accepts a cis-acting transcription factor (C protein), which regulates the counteracting activities of REase and MTase to avoid host self-restriction. Our study characterized the unexpected phenotype of Escherichia coli cells, which manifested as extensive cell filamentation triggered by acquiring the Csp231I R-M system from Citrobacter sp. Surprisingly, we found that the cell morphology defect was solely dependent on the C regulator. Our transcriptome analysis supported by in vivo and in vitro assays showed that C protein directly silenced the expression of the RacR repressor to affect the Rac prophage-related genes. The rac locus ydaST genes, when derepressed, exerted a toxicity indicated by cell filamentation through an unknown mechanism. These results provide an apparent example of transcription factor cross-talk, which can have significant consequences for the host, and may represent a constraint on lateral gene transfer.
(© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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المشرفين على المادة: 0 (DNA Restriction-Modification Enzymes)
0 (DNA, Bacterial)
0 (Transcription Factors)
0 (Viral Proteins)
EC 3.1.21.- (DNA Restriction Enzymes)
EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
تواريخ الأحداث: Date Created: 20190803 Date Completed: 20191203 Latest Revision: 20191203
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6765115
DOI: 10.1093/nar/gkz665
PMID: 31372643
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkz665