دورية أكاديمية
أعرض في EDS

The effects of spaceflight and fracture healing on distant skeletal sites.

التفاصيل البيبلوغرافية
العنوان: The effects of spaceflight and fracture healing on distant skeletal sites.
المؤلفون: Dadwal UC; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA., Maupin KA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Zamarioli A; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Ribeirão Preto Medical School, Ribeirão Preto, SP, Brazil., Tucker A; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Harris JS; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Fischer JP; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Rytlewski JD; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Scofield DC; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Wininger AE; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Bhatti FUR; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA., Alvarez M; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA., Childress PJ; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA., Chakraborty N; U.S. Army Center for Environmental Health Research, Fort Detrick, MD, USA.; Geneva Foundation, Fort Detrick, MD, USA., Gautam A; U.S. Army Center for Environmental Health Research, Fort Detrick, MD, USA., Hammamieh R; U.S. Army Center for Environmental Health Research, Fort Detrick, MD, USA., Kacena MA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. mkacena@iupui.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. mkacena@iupui.edu.
المصدر: Scientific reports [Sci Rep] 2019 Aug 06; Vol. 9 (1), pp. 11419. Date of Electronic Publication: 2019 Aug 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Space Flight*, Bone Density/*physiology , Fracture Healing/*physiology , Fractures, Bone/*surgery, Animals ; Disease Models, Animal ; Female ; Femur/diagnostic imaging ; Femur/physiology ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/physiopathology ; Humans ; Male ; Mandible/diagnostic imaging ; Mandible/physiology ; Mice ; Tibia/diagnostic imaging ; Tibia/physiology ; Weight-Bearing/physiology ; X-Ray Microtomography
مستخلص: Spaceflight results in reduced mechanical loading of the skeleton, which leads to dramatic bone loss. Low bone mass is associated with increased fracture risk, and this combination may compromise future, long-term, spaceflight missions. Here, we examined the systemic effects of spaceflight and fracture surgery/healing on several non-injured bones within the axial and appendicular skeleton. Forty C57BL/6, male mice were randomized into the following groups: (1) Sham surgery mice housed on the earth (Ground + Sham); (2) Femoral segmental bone defect surgery mice housed on the earth (Ground + Surgery); (3) Sham surgery mice housed in spaceflight (Flight + Sham); and (4) Femoral segmental bone defect surgery mice housed in spaceflight (Flight + Surgery). Mice were 9 weeks old at the time of launch and were euthanized approximately 4 weeks after launch. Micro-computed tomography (μCT) was used to evaluate standard bone parameters in the tibia, humerus, sternebra, vertebrae, ribs, calvarium, mandible, and incisor. One intriguing finding was that both spaceflight and surgery resulted in virtually identical losses in tibial trabecular bone volume fraction, BV/TV (24-28% reduction). Another important finding was that surgery markedly changed tibial cortical bone geometry. Understanding how spaceflight, surgery, and their combination impact non-injured bones will improve treatment strategies for astronauts and terrestrial humans alike.
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معلومات مُعتمدة: I01 BX003751 United States BX BLRD VA; T32 AR065971 United States AR NIAMS NIH HHS; R01 AR060863 United States AR NIAMS NIH HHS; T32 DK007519 United States DK NIDDK NIH HHS
تواريخ الأحداث: Date Created: 20190808 Date Completed: 20201027 Latest Revision: 20210110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6684622
DOI: 10.1038/s41598-019-47695-3
PMID: 31388031
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-47695-3