دورية أكاديمية
أعرض في EDS

Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study.

التفاصيل البيبلوغرافية
العنوان: Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study.
المؤلفون: Atas N; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey. nuhatas2008@gmail.com., Armagan B; Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey., Bodakci E; Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey., Satis H; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Sari A; Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey., Bilge NSY; Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey., Salman RB; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Yardımcı GK; Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey., Babaoglu H; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Guler AA; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Karadeniz H; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Kilic L; Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey., Ozturk MA; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Goker B; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Haznedaroglu S; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey., Kalyoncu U; Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey., Kasifoglu T; Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey., Tufan A; Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey.
المصدر: Rheumatology international [Rheumatol Int] 2020 Jan; Vol. 40 (1), pp. 41-48. Date of Electronic Publication: 2019 Aug 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8206885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-160X (Electronic) Linking ISSN: 01728172 NLM ISO Abbreviation: Rheumatol Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Berlin ; New York, NY] : Springer International, c1981-
مواضيع طبية MeSH: Behcet Syndrome/*epidemiology , Cryptogenic Organizing Pneumonia/*epidemiology , Familial Mediterranean Fever/*epidemiology , IgA Vasculitis/*epidemiology , Inflammatory Bowel Diseases/*epidemiology , Psoriasis/*epidemiology , Spondylarthropathies/*epidemiology , Vasculitis/*epidemiology, Adult ; Cohort Studies ; Comorbidity ; Familial Mediterranean Fever/genetics ; Familial Mediterranean Fever/physiopathology ; Humans ; Immunoglobulin A/immunology ; Middle Aged ; Pyrin/genetics ; Turkey/epidemiology ; Vasculitis/immunology ; Young Adult
مستخلص: Familial Mediterranean fever (FMF) is characterized by recurrent short-lived/self-limiting inflammatory attacks. Besides these, a substantial number of patients with FMF present with a variety of other inflammatory diseases; however, this issue has not been systematically studied previously. Hence, we aimed to investigate the frequency of inflammatory comorbid diseases in a large FMF cohort. All patients were recruited from "FMF in Central Anatolia (FiCA) Cohort", comprising 971 (mean age 35.3 ± 12 years, 61.5% female) adult subjects. All patients fulfilled Tel Hashomer criteria. Demographic data, FMF disease characteristics, MEFV gene mutations, and comorbid inflammatory diseases were meticulously questioned, and laboratory features and genotype data were retrieved from hospital records. There were comorbid inflammatory diseases in 205 (21.1%) patients. The most common inflammatory disease was spondyloarthritis (12.9%). Other remarkable inflammatory disorders were psoriasis, immunoglobulin A vasculitis/Henoch-Schönlein purpura, Behçet's disease and inflammatory bowel diseases. Cryptogenic organizing pneumonia is a newly defined entity in our cohort which is seemed to be associated with FMF (0.3%). Number of patients with persistent inflammation was higher in those with comorbid diseases (p < 0.001). Our results suggest that FMF is commonly associated with other inflammatory diseases. Therefore, clinicians should be cautious about comorbid inflammatory diseases in FMF patients, particularly in those with persistent inflammation. Identification of pathogenic pathways linking FMF to these diseases warrants further investigations.
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فهرسة مساهمة: Keywords: Comorbidity; Familial Mediterranean fever; Inflammation; Interleukin-1 β; Spondyloarthritis
المشرفين على المادة: 0 (Immunoglobulin A)
0 (MEFV protein, human)
0 (Pyrin)
تواريخ الأحداث: Date Created: 20190809 Date Completed: 20210212 Latest Revision: 20211204
رمز التحديث: 20240829
DOI: 10.1007/s00296-019-04412-7
PMID: 31392498
قاعدة البيانات: MEDLINE
الوصف
تدمد:1437-160X
DOI:10.1007/s00296-019-04412-7