دورية أكاديمية
أعرض في EDS

Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice.

التفاصيل البيبلوغرافية
العنوان: Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice.
المؤلفون: Jacobs SAH; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Gart E; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands.; Human and Animal Physiology, Wageningen University, 6700 AH Wageningen, The Netherlands., Vreeken D; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Franx BAA; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Wekking L; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Verweij VGM; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Worms N; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands., Schoemaker MH; Reckitt Benckiser Health, Mead Johnson Pediatric Nutrition Institute, 6545 CJ Nijmegen, The Netherlands., Gross G; Reckitt Benckiser Health, Mead Johnson Pediatric Nutrition Institute, 6545 CJ Nijmegen, The Netherlands., Morrison MC; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands.; Human and Animal Physiology, Wageningen University, 6700 AH Wageningen, The Netherlands., Kleemann R; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands.; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Arnoldussen IAC; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands., Kiliaan AJ; Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, 6500 HB Nijmegen, The Netherlands. amanda.kiliaan@radboudumc.nl.
المصدر: Nutrients [Nutrients] 2019 Aug 10; Vol. 11 (8). Date of Electronic Publication: 2019 Aug 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Sex Factors*, Diet, High-Fat/*adverse effects , Non-alcoholic Fatty Liver Disease/*etiology , Obesity/*metabolism , Obesity/*pathology, Adipose Tissue/metabolism ; Animals ; Brain/pathology ; Female ; Lipid Metabolism ; Liver/pathology ; Male ; Mice ; Mice, Obese ; Obesity/complications ; Receptors, LDL/deficiency
مستخلص: Background: Sex-specific differences play a role in metabolism, fat storage in adipose tissue, and brain structure. At juvenile age, brain function is susceptible to the effects of obesity; little is known about sex-specific differences in juvenile obesity. Therefore, this study examined sex-specific differences in adipose tissue and liver of high-fat diet (HFD)-induced obese mice, and putative alterations between male and female mice in brain structure in relation to behavioral changes during the development of juvenile obesity.
Methods: In six-week-old male and female Ldlr-/-.Leiden mice (n = 48), the impact of 18 weeks of HFD-feeding was examined. Fat distribution, liver pathology and brain structure and function were analyzed imunohisto- and biochemically, in cognitive tasks and with MRI.
Results: HFD-fed female mice were characterized by an increased perigonadal fat mass, pronounced macrovesicular hepatic steatosis and liver inflammation. Male mice on HFD displayed an increased mesenteric fat mass, pronounced adipose tissue inflammation and microvesicular hepatic steatosis. Only male HFD-fed mice showed decreased cerebral blood flow and reduced white matter integrity.
Conclusions: At young age, male mice are more susceptible to the detrimental effects of HFD than female mice. This study emphasizes the importance of sex-specific differences in obesity, liver pathology, and brain function.
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فهرسة مساهمة: Keywords: juvenile; obesity; sex
المشرفين على المادة: 0 (Receptors, LDL)
تواريخ الأحداث: Date Created: 20190814 Date Completed: 20200204 Latest Revision: 20200225
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6723313
DOI: 10.3390/nu11081861
PMID: 31405127
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu11081861