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Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury.

التفاصيل البيبلوغرافية
العنوان: Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury.
المؤلفون: Rodrigues KE; Neuroscience and Cellular Biology Post Graduation Program, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., de Oliveira FR; Neuroscience and Cellular Biology Post Graduation Program, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil; Bromatology and Quality Control Laboratory, Health and Biological Sciences Department, Federal University of Amapa (UNIFAP), Macapa, Ap, Brazil., Barbosa BRC; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., Paraense RSO; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., Bannwart CM; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., Pinheiro BG; Behavioral and Inflammatory Pharmacology Laboratory, Health Sciences Institute, Pharmacy College, Federal University of Para, Belem, PA, Brazil., Botelho AS; Chemical Analysis Laboratory, Museum Paraense Emílio Goeldi, Belem, PA, Brazil., Muto NA; Amazonian Bioactive Compounds Valorization Center, Federal University of Para, Belem, PA, Brazil., do Amarante CB; Chemical Analysis Laboratory, Museum Paraense Emílio Goeldi, Belem, PA, Brazil., Hamoy M; Natural Products' Toxicology and Pharmacology Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., Macchi BM; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., Maia CDSF; Behavioral and Inflammatory Pharmacology Laboratory, Health Sciences Institute, Pharmacy College, Federal University of Para, Belem, PA, Brazil., do Prado AF; Structural Biology Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil., do Nascimento JLM; Neuroscience and Cellular Biology Post Graduation Program, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil; Molecular and Cellular Neurochemistry Laboratory, Biological Sciences Institute, Federal University of Para, Belem, PA, Brazil; National Institute of Science and Technology in Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, RJ, Brazil; Pharmaceutical Sciences Post Graduation Program, Health and Biological Sciences Department, Federal University of Amapa (UNIFAP), Macapa, Ap, Brazil. Electronic address: jlmn@ufpa.br.
المصدر: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Nov; Vol. 133, pp. 110755. Date of Electronic Publication: 2019 Aug 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Exeter : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, c1982-
مواضيع طبية MeSH: Coriandrum/*chemistry , Mercury Poisoning, Nervous System/*prevention & control , Methylmercury Compounds/*toxicity , Neuroprotection/*drug effects , Neuroprotective Agents/*therapeutic use , Plant Extracts/*therapeutic use, Animals ; Cerebellum/drug effects ; Female ; Lipid Peroxidation/drug effects ; Locomotion/drug effects ; Male ; Maternal Exposure ; Motor Activity/drug effects ; Movement Disorders/prevention & control ; Neuroprotective Agents/isolation & purification ; Oxidative Stress/drug effects ; Plant Extracts/isolation & purification ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Pregnancy ; Rats ; Reactive Oxygen Species/metabolism
مستخلص: This study aimed to investigate the effects of Coriandrum sativum aqueous extract (CSAE) on the rat progeny of mothers exposed to methylmercury (MeHg). The presence of bioactive compounds and CSAE's antioxidant capacity been evaluated, and the offspring were assessed for their total mercury levels, motor behavioral parameters and oxidative stress in the cerebellum. The analysis of the bioactive compounds revealed significant amounts of polyphenols, flavonoids, and anthocyanins, as well as a variety of minerals. A DPPH test showed the CSAE had important antioxidant activity. The MeHg + CSAE group performed significantly better spontaneous locomotor activity, palmar grip strength, balance, and motor coordination in behavioral tests compared the MeHg group, as well as in the parameters of oxidative stress, with similar results to those of the control group. The MeHg + CSAE group also had significantly reduced mercury levels in comparison to the MeHg group. Based on the behavioral tests, which detected large locomotor, balance, and coordination improvements, as well as a reduction in oxidative stress, we conclude that CSAE had positive functional results in the offspring of rats exposed to MeHg.
(Copyright © 2019. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Behavioral parameters; Coriandrum sativum; Methylmercury; Oxidative stress; Rat offspring
المشرفين على المادة: 0 (Methylmercury Compounds)
0 (Neuroprotective Agents)
0 (Plant Extracts)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20190814 Date Completed: 20200113 Latest Revision: 20200113
رمز التحديث: 20221213
DOI: 10.1016/j.fct.2019.110755
PMID: 31408720
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6351
DOI:10.1016/j.fct.2019.110755