دورية أكاديمية
أعرض في EDS

Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules.

التفاصيل البيبلوغرافية
العنوان: Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules.
المؤلفون: Kamijo A; Health Science Division, Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, 3-1-1 Asahi, Matsumoto City, Nagano, 390-8621, Japan., Saitoh Y; Health Science Division, Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, 3-1-1 Asahi, Matsumoto City, Nagano, 390-8621, Japan.; Center for Medical Education, Teikyo University of Science, Adachi-ku, Tokyo, Japan., Sakamoto T; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan., Kubota H; Laboratory of Cell and Molecular Biology, Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan., Yamauchi J; Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji City, Tokyo, Japan., Terada N; Health Science Division, Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, 3-1-1 Asahi, Matsumoto City, Nagano, 390-8621, Japan. nobuot@shinshu-u.ac.jp.
المصدر: Histochemistry and cell biology [Histochem Cell Biol] 2019 Nov; Vol. 152 (5), pp. 333-343. Date of Electronic Publication: 2019 Aug 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer,
مواضيع طبية MeSH: Guanylate Kinases/*analysis , Lipid-Linked Proteins/*analysis , Seminiferous Tubules/*chemistry , Vesicular Transport Proteins/*analysis, Animals ; Cells, Cultured ; Guanylate Kinases/deficiency ; Guanylate Kinases/metabolism ; Lipid-Linked Proteins/deficiency ; Lipid-Linked Proteins/metabolism ; Male ; Membrane Proteins ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Seminiferous Tubules/metabolism ; Vesicular Transport Proteins/metabolism
مستخلص: The membrane skeletal complex, protein 4.1G-membrane palmitoylated protein 6 (MPP6), is localized in spermatogonia and early spermatocytes of mouse seminiferous tubules. In this study, we investigated the Lin7 family of scaffolding proteins, which interact with MPP6. By immunohistochemistry, Lin7a and Lin7c were localized in germ cells, and Lin7c had especially strong staining in spermatogonia and early spermatocytes, characterized by staging of seminiferous tubules. By immunoelectron microscopy, Lin7 localization appeared under cell membranes in germ cells. The Lin7 staining pattern in seminiferous tubules was partially similar to that of 4.1G, cell adhesion molecule 1 (CADM1), and melanoma cell adhesion molecule (MCAM). Lin7-positive cells included type A spermatogonia, as revealed by double staining for Lin28a. Lin7 staining became weaker in MPP6-deficient mice by immunohistochemistry and western blotting, indicating that MPP6 transports and maintains Lin7 in germ cells. The histology of seminiferous tubules was unchanged in MPP6-deficient mice compared to that of wild-type mice. In cultured spermatogonial stem cells maintained with glial cell line-derived neurotropic factor (GDNF), Lin7 was clearly expressed and immunolocalized along cell membranes, especially at cell-cell junctions. Thus, Lin7 protein is expressed in germ cells, and Lin7, particularly Lin7c, is a useful marker for early spermatogenesis.
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فهرسة مساهمة: Keywords: Lin7; Membrane palmitoylated proteins; Membrane skeletal protein; Seminiferous tubule; Spermatogonia
المشرفين على المادة: 0 (Lin7a protein, mouse)
0 (Lipid-Linked Proteins)
0 (MPP6 protein, mouse)
0 (Membrane Proteins)
0 (Vesicular Transport Proteins)
EC 2.7.4.8 (Guanylate Kinases)
تواريخ الأحداث: Date Created: 20190815 Date Completed: 20191206 Latest Revision: 20201209
رمز التحديث: 20231215
DOI: 10.1007/s00418-019-01807-2
PMID: 31410570
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-119X
DOI:10.1007/s00418-019-01807-2