دورية أكاديمية
أعرض في EDS

Risk factors and role of low molecular weight heparin in obstetric complications among women with inherited thrombophilia - a cohort study.

التفاصيل البيبلوغرافية
العنوان: Risk factors and role of low molecular weight heparin in obstetric complications among women with inherited thrombophilia - a cohort study.
المؤلفون: Clavijo MM; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: mclavijo@hospitalaleman.com., Mahuad CV; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina., Reparaz MLAV; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina., Aizpurua MF; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina., Ventura A; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina., Casali CE; Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina.
المصدر: Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2019 Oct - Dec; Vol. 41 (4), pp. 303-309. Date of Electronic Publication: 2019 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Editora Ltda Country of Publication: Brazil NLM ID: 101725732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2531-1387 (Electronic) Linking ISSN: 25311379 NLM ISO Abbreviation: Hematol Transfus Cell Ther Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Rio de Janeiro, Brazil] : Elsevier Editora Ltda, [2018]-
مستخلص: Introduction: Although there is a vast literature regarding the association between inherited thrombophilia, obstetric complications and the effect of low molecular weight heparin (LMWH), these are controversial and we have not found publications related to additional risk factors other than thrombophilia. Our objectives were to assess the prevalence of miscarriage, placenta-mediated pregnancy complications and fetal loss in pregnant women with IT, establishing associated risk factors and the effect of LMWH.
Materials and Methods: A retrospective cohort of pregnant women with IT was formed. Risk factors considered were: high-risk IT, age ≥35 years, body mass index ≥25 and ≥30, assisted reproductive technology, antiphospholipid antibodies, autoimmune disease, first-degree family history of obstetric complications and personal history of venous or arterial thromboembolic disease, the outcomes being M, FL and PMPC.
Results and Conclusions: Data from 250 pregnancies in 88 women were obtained. There were 112 (45%) Ms, 13 (5.2%) FLs and 25 (10%) PMPCs. High-risk IT was associated with FL (OR=4.96; 95% CI, 1.42-17.3). Antiphospholipid antibodies and family history of obstetric complications were associated with PMPC (OR=7.12; 95% CI, 1.89-26.74, OR=3.88; 95% CI, 1.18-12.78, respectively). The LMWH presented a benefit in the combined outcome (any obstetric complication, OR=0.25; 95% CI, 0.12-0.54) and M (OR=0.41; 95% CI, 0.20-0.82). We conclude that obstetric complications are common in women with IT. Antiphospholipid antibodies, family history of obstetric complications and high-risk IT might be additional risk factors. The LMWH has an apparent protective effect against obstetric complications, which is consistent with some previous studies.
(Copyright © 2019 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.)
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فهرسة مساهمة: Keywords: Abortion; Inherited thrombophilia; LMWH; Miscarriage; Pregnancy loss
تواريخ الأحداث: Date Created: 20190816 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6978538
DOI: 10.1016/j.htct.2019.03.003
PMID: 31412985
قاعدة البيانات: MEDLINE
الوصف
تدمد:2531-1387
DOI:10.1016/j.htct.2019.03.003