دورية أكاديمية

Molecular Biomarkers of Brain and Spinal Cord Astrocytomas.

التفاصيل البيبلوغرافية
العنوان: Molecular Biomarkers of Brain and Spinal Cord Astrocytomas.
المؤلفون: Konovalov NA; National Medical Research Center of Neurosurgery, Ministry of Health of the Russian Federation Acad. N.N. Burdenko, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia., Asyutin DS; National Medical Research Center of Neurosurgery, Ministry of Health of the Russian Federation Acad. N.N. Burdenko, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia., Shayhaev EG; FGBU Russian Research Center for X-ray Radiology of the Ministry of Health of the Russian Federation Profsouznaya Str. 86, Moscow, 117485, Russia., Kaprovoy SV; National Medical Research Center of Neurosurgery, Ministry of Health of the Russian Federation Acad. N.N. Burdenko, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia., Timonin SY; National Medical Research Center of Neurosurgery, Ministry of Health of the Russian Federation Acad. N.N. Burdenko, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia.
المصدر: Acta naturae [Acta Naturae] 2019 Apr-Jun; Vol. 11 (2), pp. 17-27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Research University Higher School of Economics Country of Publication: Russia (Federation) NLM ID: 101525823 Publication Model: Print Cited Medium: Print ISSN: 2075-8251 (Print) Linking ISSN: 20758251 NLM ISO Abbreviation: Acta Naturae Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2019- : [Moscow] : National Research University Higher School of Economics
Original Publication: Moscow : Park Media Ltd
مستخلص: Spinal cord astrocytomas are rare diseases of the central nervous system. The localization of these tumors and their infiltrative growth complicate their surgical resection, increase the risk of postoperative complications, and require more careful use of radio- and chemotherapy. The information on the genetic mutations associated with the onset and development of astrocytomas provides a more accurate neoplasm diagnosis and classification. In some cases, it also allows one to determine the optimal methods for treating the neoplasm, as well as to predict the treatment outcomes and the risks of relapse. To date, a number of molecular markers that are associated with brain astrocytomas and possess prognostic value have been identified and described. Due to the significantly lower incidence of spinal cord astrocytomas, the data on similar markers are much more sparse and are presented with a lesser degree of systematization. However, due to the retrospective studies of clinical material that have been actively conducted abroad in recent years, the formation of statistically significant genetic landscapes for various types of tumors, including intradural spinal cord tumors, has begun. In this regard, the purpose of this review is to analyze and systematize the information on the most significant genetic mutations associated with various types of astrocytomas, as well as discuss the prospects for using the corresponding molecular markers for diagnostic and prognostic purposes.
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فهرسة مساهمة: Keywords: diagnosis; glioblastoma; mechanisms of neoplastic transformation; molecular markers; mutations; prognostic value; spinal cord astrocytoma
تواريخ الأحداث: Date Created: 20190816 Latest Revision: 20240718
رمز التحديث: 20240718
مُعرف محوري في PubMed: PMC6643348
DOI: 10.32607/20758251-2019-11-2-17-27
PMID: 31413876
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-8251
DOI:10.32607/20758251-2019-11-2-17-27