دورية أكاديمية
أعرض في EDS

Hypertension and progressive supranuclear palsy.

التفاصيل البيبلوغرافية
العنوان: Hypertension and progressive supranuclear palsy.
المؤلفون: Rabadia SV; University of California San Diego Department of Neurosciences, USA., Litvan I; University of California San Diego Department of Neurosciences, USA. Electronic address: ilitvan@ucsd.edu., Juncos J; Emory University, USA., Bordelon Y; University of California Los Angeles, USA., Riley DE; Case Western Reserve University, USA., Standaert D; University of Alabama in Birmingham, USA., Reich SG; University of Maryland, USA., Hall DA; University of Colorado, USA; Rush University, USA., Kluger B; University of Colorado, USA., Shprecher D; University of Utah, USA; Banner Sun Health Research Institute, USA., Marras C; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, USA., Jankovic J; Baylor College of Medicine, USA.
مؤلفون مشاركون: ENGENE PSP study
المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2019 Sep; Vol. 66, pp. 166-170. Date of Electronic Publication: 2019 Aug 03.
نوع المنشور: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kidlington, Oxford, U.K. ; Tarrytown, NY : Elsevier Science, c1995-
مواضيع طبية MeSH: Hypertension/*epidemiology , Supranuclear Palsy, Progressive/*epidemiology, Aged ; Case-Control Studies ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Risk Factors
مستخلص: Background: The epidemiologic evidence of whether hypertension is associated with Progressive Supranuclear Palsy (PSP) is inconsistent. The ENGENE-PSP case-control study determined various PSP risk factors including whether hypertension preceded PSP onset.
Methods: Incident PSP cases per NINDS-PSP criteria and age-, sex-, race- matched controls were recruited from similar North American geographic areas. All study participants were administered standardized interviews to obtain data on demographics, medical history and medications.
Statistics: We used univariate and multivariate conditional logistic regression models to measure the associations between PSP and the following predictor variables: education level, hypertension, comorbid vascular conditions (diabetes mellitus and hyperlipidemia), and classes of anti-hypertensive medications using odds ratios and 95% confidence intervals.
Results: There were significant associations seen between PSP and hypertension (OR: 1.569; 95% CI 1.129-2.181; p-value = 0.007), education level (OR: 0.733; 95% CI 0.637-0.843; p-value<0.001) and beta-blocker use (OR: 2.000; 95% CI 1.053-3.799; p-value = 0.034). However, in the multi-variate analysis hypertension (OR: 1.492; 95% CI 1.045-2.129; p-value = 0.027) and education level (OR: 0.730; 95% CI 0.633-0.841; p-value<0.001) were the only significant associations.
Conclusion: These results suggest that there is a modest, yet significant association between hypertension and PSP. Further studies will be needed to better understand the pathophysiological basis for this finding.
(Copyright © 2019. Published by Elsevier Ltd.)
معلومات مُعتمدة: R01 AG024040 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Case-control study; Epidemiology; Hypertension; Progressive supranuclear palsy; Risk factors
تواريخ الأحداث: Date Created: 20190818 Date Completed: 20200804 Latest Revision: 20200804
رمز التحديث: 20231215
DOI: 10.1016/j.parkreldis.2019.07.036
PMID: 31420308
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-5126
DOI:10.1016/j.parkreldis.2019.07.036