Inhibitory role of G i -coupled receptors on cAMP-driven cancers with focus on opioid receptors in lung adenocarcinoma and its stem cells.

التفاصيل البيبلوغرافية
العنوان:	Inhibitory role of G i -coupled receptors on cAMP-driven cancers with focus on opioid receptors in lung adenocarcinoma and its stem cells.
المؤلفون:	Schuller HM; Department of Biomedical & Diagnostic Science, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, United States. Electronic address: schullerhildegard@gmail.com.
المصدر:	Vitamins and hormones [Vitam Horm] 2019; Vol. 111, pp. 299-311. Date of Electronic Publication: 2019 Jun 21.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Academic Press Country of Publication: United States NLM ID: 0413601 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0083-6729 (Print) Linking ISSN: 00836729 NLM ISO Abbreviation: Vitam Horm Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: New York, Academic Press.
مواضيع طبية MeSH:	Adenocarcinoma of Lung/drug therapy , Cyclic AMP/pharmacology , GTP-Binding Protein alpha Subunits, Gi-Go/metabolism , Lung Neoplasms/drug therapy , Receptors, G-Protein-Coupled/physiology , Receptors, Opioid/physiology, Adenylyl Cyclase Inhibitors ; Adenylyl Cyclases/pharmacology ; Animals ; Anticarcinogenic Agents/pharmacology ; Cannabinoids/pharmacology ; Cyclic AMP/metabolism ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Humans ; Methadone/pharmacology ; Narcotic Antagonists ; Receptors, G-Protein-Coupled/drug effects ; Signal Transduction/physiology ; Stem Cells/drug effects ; Stem Cells/physiology
مستخلص:	The development, progression, metastasis and drug resistance of the most common human cancers are driven by cyclic adenosine monophosphate (cAMP)-signaling downstream of beta-adrenergic receptors (β-Ars) coupled to the stimulatory G-protein G s . Receptors coupled to the inhibitory G-protein G i inhibit this signaling cascade by blocking the activation of the enzyme adenylyl cyclase that catalyzes the formation of cAMP and function as the physiological inhibitors of this signaling cascade. Members of the G i -coupled receptor family widely expressed in the mammalian organism are GABA B receptors (GABA B -Rs) for the inhibitory neurotransmitter γ-aminobutyric acid (GABA), opioid receptors for endogenous opioid peptides and cannabinoid receptors for endogenous cannabinoids. This review summarizes current evidence for the concept that the activation of G i -receptor signaling by pharmacological and psychological means is a promising tool for the long-term management of cAMP-driven cancers with special emphasis on the inhibitory effects of opioids on lung adenocarcinoma and its stem cells. (© 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة:	Keywords: Beta-adrenergic receptors; Cancer; Cancer stem cells; Cannabinoid receptors; GABA(B)-receptors; Lung adenocarcinoma; Methadone; Opioid receptors
المشرفين على المادة:	0 (Adenylyl Cyclase Inhibitors) 0 (Anticarcinogenic Agents) 0 (Cannabinoids) 0 (Narcotic Antagonists) 0 (Receptors, G-Protein-Coupled) 0 (Receptors, Opioid) E0399OZS9N (Cyclic AMP) EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go) EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gs) EC 4.6.1.1 (Adenylyl Cyclases) UC6VBE7V1Z (Methadone)
تواريخ الأحداث:	Date Created: 20190819 Date Completed: 20200326 Latest Revision: 20200326
رمز التحديث:	20231215
DOI:	10.1016/bs.vh.2019.05.009
PMID:	31421705
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	0083-6729
DOI:	10.1016/bs.vh.2019.05.009