دورية أكاديمية
Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism.
| العنوان: | Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism. |
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| المؤلفون: | Navarro SL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Tarkhan A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Shojaie A; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Randolph TW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Gu H; College of Health Solutions, Arizona State University, Phoenix, AZ, USA., Djukovic D; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Osterbauer KJ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hullar MA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kratz M; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Neuhouser ML; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lampe PD; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Raftery D; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Lampe JW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
| المصدر: | The American journal of clinical nutrition [Am J Clin Nutr] 2019 Oct 01; Vol. 110 (4), pp. 984-992. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0376027 Publication Model: Print Cited Medium: Internet ISSN: 1938-3207 (Electronic) Linking ISSN: 00029165 NLM ISO Abbreviation: Am J Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: Bethesda, MD : American Society of Clinical Nutrition |
| مواضيع طبية MeSH: | Diet* , Glycemic Load* , Metabolomics*, Inflammation/*metabolism, Adolescent ; Adult ; Biomarkers/blood ; Energy Metabolism/physiology ; Feeding Behavior ; Female ; Humans ; Male ; Metabolome ; Young Adult |
| مستخلص: | Background: Low-glycemic load dietary patterns, characterized by consumption of whole grains, legumes, fruits, and vegetables, are associated with reduced risk of several chronic diseases. Methods: Using samples from a randomized, controlled, crossover feeding trial, we evaluated the effects on metabolic profiles of a low-glycemic whole-grain dietary pattern (WG) compared with a dietary pattern high in refined grains and added sugars (RG) for 28 d. LC-MS-based targeted metabolomics analysis was performed on fasting plasma samples from 80 healthy participants (n = 40 men, n = 40 women) aged 18-45 y. Linear mixed models were used to evaluate differences in response between diets for individual metabolites. Kyoto Encyclopedia of Genes and Genomes (KEGG)-defined pathways and 2 novel data-driven analyses were conducted to consider differences at the pathway level. Results: There were 121 metabolites with detectable signal in >98% of all plasma samples. Eighteen metabolites were significantly different between diets at day 28 [false discovery rate (FDR) < 0.05]. Inositol, hydroxyphenylpyruvate, citrulline, ornithine, 13-hydroxyoctadecadienoic acid, glutamine, and oxaloacetate were higher after the WG diet than after the RG diet, whereas melatonin, betaine, creatine, acetylcholine, aspartate, hydroxyproline, methylhistidine, tryptophan, cystamine, carnitine, and trimethylamine were lower. Analyses using KEGG-defined pathways revealed statistically significant differences in tryptophan metabolism between diets, with kynurenine and melatonin positively associated with serum C-reactive protein concentrations. Novel data-driven methods at the metabolite and network levels found correlations among metabolites involved in branched-chain amino acid (BCAA) degradation, trimethylamine-N-oxide production, and β oxidation of fatty acids (FDR < 0.1) that differed between diets, with more favorable metabolic profiles detected after the WG diet. Higher BCAAs and trimethylamine were positively associated with homeostasis model assessment-insulin resistance. Conclusions: These exploratory metabolomics results support beneficial effects of a low-glycemic load dietary pattern characterized by whole grains, legumes, fruits, and vegetables, compared with a diet high in refined grains and added sugars on inflammation and energy metabolism pathways. This trial was registered at clinicaltrials.gov as NCT00622661. (Copyright © American Society for Nutrition 2019.) |
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| معلومات مُعتمدة: | K01 HL124050 United States HL NHLBI NIH HHS; P30 CA015704 United States CA NCI NIH HHS; U54 CA116847 United States CA NCI NIH HHS; R01 CA192222 United States CA NCI NIH HHS; P30 DK035816 United States DK NIDDK NIH HHS; R01 GM114029 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: crossover; dietary intervention; dietary patterns; glycemic load; inflammation; insulin resistance; metabolomics; whole grains |
| سلسلة جزيئية: | ClinicalTrials.gov NCT00622661 |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20190822 Date Completed: 20200323 Latest Revision: 20230214 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6766441 |
| DOI: | 10.1093/ajcn/nqz169 |
| PMID: | 31432072 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1938-3207 |
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| DOI: | 10.1093/ajcn/nqz169 |