دورية أكاديمية
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.
| العنوان: | Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. |
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| المؤلفون: | Binderup T; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark., Duivenvoorden R; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, Netherlands., Fay F; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Institut Galien Paris Sud, Faculté de Pharmacie, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92290 Châtenay-Malabry, France., van Leent MMT; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Malkus J; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Baxter S; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ishino S; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhao Y; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sanchez-Gaytan B; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Teunissen AJP; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Frederico YCA; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Tang J; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Carlucci G; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Bernard and Irene Schwarz Center for Biomedical Imaging, New York University, New York, NY 10016, USA., Lyashchenko S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA., Calcagno C; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Karakatsanis N; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Soultanidis G; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Senders ML; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, Netherlands., Robson PM; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mani V; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ramachandran S; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lobatto ME; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Radiology, Spaarne Gasthuis, 2035 RC Haarlem, Netherlands., Hutten BA; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands., Granada JF; CRF Skirball Center for Innovation, Cardiovascular Research Foundation, Orangeburg, NY 10962, USA., Reiner T; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA., Swirski FK; Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Nahrendorf M; Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Kjaer A; Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark., Fisher EA; Department of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY 10016, USA., Fayad ZA; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. willem.mulder@mssm.edu zahi.fayad@mssm.edu., Pérez-Medina C; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain., Mulder WJM; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. willem.mulder@mssm.edu zahi.fayad@mssm.edu.; Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands. |
| المصدر: | Science translational medicine [Sci Transl Med] 2019 Aug 21; Vol. 11 (506). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Imaging, Three-Dimensional* , Immunotherapy* , Nanomedicine*, Atherosclerosis/*immunology , Atherosclerosis/*therapy, Animals ; Apolipoproteins E/deficiency ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/drug therapy ; Disease Models, Animal ; Female ; Lipoproteins, HDL/metabolism ; Lipoproteins, HDL/toxicity ; Magnetic Resonance Imaging ; Male ; Mice, Inbred C57BL ; Positron-Emission Tomography ; Rabbits ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Species Specificity ; Swine ; Tissue Distribution |
| مستخلص: | Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges. Specifically, we integrated translational imaging readouts within our workflow to both analyze the nanoimmunotherapeutic's in vivo behavior and assess treatment response in larger animals. We observed our nanoimmunotherapeutic's anti-inflammatory efficacy in mice, as well as rabbits and pigs. Nanoimmunotherapy-mediated reduction of inflammation in the large animal models halted plaque progression, supporting the approach's translatability and potential to acutely treat atherosclerosis. (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.) |
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| معلومات مُعتمدة: | R01 HL125703 United States HL NHLBI NIH HHS; R01 HL144072 United States HL NHLBI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R01 EB009638 United States EB NIBIB NIH HHS; R01 HL118440 United States HL NHLBI NIH HHS; R01 HL071021 United States HL NHLBI NIH HHS; P01 HL131478 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Apolipoproteins E) 0 (Lipoproteins, HDL) AGG2FN16EV (Simvastatin) |
| تواريخ الأحداث: | Date Created: 20190823 Date Completed: 20200814 Latest Revision: 20240216 |
| رمز التحديث: | 20240216 |
| مُعرف محوري في PubMed: | PMC7328283 |
| DOI: | 10.1126/scitranslmed.aaw7736 |
| PMID: | 31434756 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aaw7736 |