دورية أكاديمية
أعرض في EDS

Clinical differences between patients with pediatric bipolar disorder with and without a parental history of bipolar disorder.

التفاصيل البيبلوغرافية
العنوان: Clinical differences between patients with pediatric bipolar disorder with and without a parental history of bipolar disorder.
المؤلفون: Ramos BR; Pediatric Bipolar Disorder Research Program, ProCAB and Laboratory of Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento - Faculdade de Medicina, UFRGS, Porto Alegre, RS, Brazil., Librenza-Garcia D; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento - Faculdade de Medicina, UFRGS, Porto Alegre, RS, Brazil; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada., Zortea F; Pediatric Bipolar Disorder Research Program, ProCAB and Laboratory of Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil., Watts D; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada., Zeni CP; Department of Psychiatry and Behavioural Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston. TX USA., Tramontina S; Pediatric Bipolar Disorder Research Program, ProCAB and Laboratory of Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil., Passos IC; Pediatric Bipolar Disorder Research Program, ProCAB and Laboratory of Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento - Faculdade de Medicina, UFRGS, Porto Alegre, RS, Brazil. Electronic address: ivescp1@gmail.com.
المصدر: Psychiatry research [Psychiatry Res] 2019 Oct; Vol. 280, pp. 112501. Date of Electronic Publication: 2019 Aug 10.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Bipolar Disorder/*genetics , Bipolar Disorder/*psychology , Child of Impaired Parents/*psychology , Parents/*psychology , Suicide, Attempted/*psychology, Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/genetics ; Attention Deficit Disorder with Hyperactivity/psychology ; Bipolar Disorder/diagnosis ; Child ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Suicide, Attempted/trends
مستخلص: Pediatric Bipolar Disorder (PBD) is a highly heritable condition responsible for 18% of all pediatric mental health hospitalizations. Despite the heritability of this disorder, few studies have assessed potential differences in the clinical manifestation of PBD among patients with a clear parental history of BD. Additionally, while recent studies suggest that attentional deficits are a potential endophenotypic marker of PBD, it is unclear whether heritability is a relevant contributor to these symptoms. In order to address this gap, the present study assessed 61 youth with PBD (6-17 years old), corresponding to 27 offspring of BD patients, and 31 PBD patients without a parental history of the disorder. All standardized assessments, including the K-SADS-PL-W were performed by trained child and adolescent psychiatrists. We performed a logistic multivariate model using the variables of ADHD, rapid cycling, and lifetime psychosis. Rates of ADHD comorbidity were significantly higher among PBD patients who had a parent with BD. Furthermore, PBD patients who had a parent with BD showed a trend toward significance of earlier symptom onset. PBD offspring did not show increased rates of suicide attempts, rapid cycling, or psychosis. Given these findings, it appears that PBD patients who have a parent with BD may represent a distinct endophenotype of the disorder. Future longitudinal and larger studies are required to confirm our findings.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: ADHD; Bipolar disorder; Offspring; Pediatric; Psychosis; Suicide
تواريخ الأحداث: Date Created: 20190823 Date Completed: 20200407 Latest Revision: 20200408
رمز التحديث: 20221213
DOI: 10.1016/j.psychres.2019.112501
PMID: 31437660
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7123
DOI:10.1016/j.psychres.2019.112501