دورية أكاديمية
Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells.
| العنوان: | Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells. |
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| المؤلفون: | Vuolo MM; School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas, SP, Brazil., Batista ÂG; School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas, SP, Brazil; Department of Food and Nutrition, Federal University of Santa Maria (UFSM), Palmeira das Missões, RS 98300-000, Brazil., Biasoto ACT; Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, Petrolina, PE 56302-970, Brazil., Correa LC; Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, Petrolina, PE 56302-970, Brazil., Júnior MRM; School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas, SP, Brazil. Electronic address: mmarosti@unicamp.br., Liu RH; Department of Food Science, Cornell University, Ithaca, NY ZIP 14850-2824, USA. |
| المصدر: | Food research international (Ottawa, Ont.) [Food Res Int] 2019 Oct; Vol. 124, pp. 93-100. Date of Electronic Publication: 2018 Aug 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| مواضيع طبية MeSH: | Antioxidants/*pharmacology , Cell Proliferation/*drug effects , Fruit/*chemistry , Plant Extracts/*pharmacology , Syzygium/*chemistry, Antioxidants/chemistry ; Cell Survival/drug effects ; Hep G2 Cells ; Humans ; Plant Extracts/chemistry |
| مستخلص: | The peel of the red-jambo concentrates the majority of the bioactive compounds and antioxidant capacity of the fruit. Minor phenolic compounds in this part of the fruit are still unknown, as well as the effect of its extracts in in vitro and in vivo studies. In an ethanolic extract of red-jambo, a wider range of phenolic compounds was investigated and the antioxidant cellular antioxidant activity and inhibition of HepG2 cell proliferation were evaluated for the first time. Using HPLC-FLD/DAD for phenolic compounds determination, gallic acid, chlorogenic acid and (-)-epigallocatechin gallate were found for the first time in the peel of the red-jambo fruit. The anthocyanins found (cyanidin 3,5-diglucoside, cyanidin 3-glucoside and peonidin 3-glucoside) were the flavonoid class strongly correlated with the antioxidant capacity methods used in this study (cellular antioxidant activity and oxygen radical absorbance capacity). The ethanolic extract of the peel showed significant effect on reducing the tumoral cell growth and proliferation. Antiproliferative activity of phytochemicals showed no significant correlative relations with total phenolic compounds, flavonoids and anthocyanins, demonstrating which the antiproliferative effect of the extract could be due to the synergic action among the compounds in red-jambo peel. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antiproliferative activity; Cellular antioxidant activity; Malay apple; Myrtaceae; Syzygium malaccence |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20190831 Date Completed: 20200928 Latest Revision: 20200928 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.foodres.2018.08.040 |
| PMID: | 31466655 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7145 |
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| DOI: | 10.1016/j.foodres.2018.08.040 |