دورية أكاديمية
أعرض في EDS

Analysis of the 56-kDa type specific antigen gene of Orientia tsutsugamushi from northern Vietnam.

التفاصيل البيبلوغرافية
العنوان: Analysis of the 56-kDa type specific antigen gene of Orientia tsutsugamushi from northern Vietnam.
المؤلفون: Trung NV; National Hospital for Tropical Diseases, Hanoi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., Hoi LT; National Hospital for Tropical Diseases, Hanoi, Vietnam., Cuong DD; Bach Mai Hospital, Hanoi, Vietnam., Ha DT; Hanoi Medical University, Hanoi, Vietnam., Hoa TM; National Hospital for Tropical Diseases, Hanoi, Vietnam., Lien VN; National Hospital for Tropical Diseases, Hanoi, Vietnam., Hoa NT; National Hospital for Tropical Diseases, Hanoi, Vietnam., Hoa LNM; National Hospital for Tropical Diseases, Hanoi, Vietnam., Huong DT; National Hospital for Tropical Diseases, Hanoi, Vietnam., Bich VTN; Oxford University Clinical Research Unit, Wellcome Trust Asia Program, Hanoi, Vietnam., van Doorn HR; Oxford University Clinical Research Unit, Wellcome Trust Asia Program, Hanoi, Vietnam., Nadjm B; Oxford University Clinical Research Unit, Wellcome Trust Asia Program, Hanoi, Vietnam., Richards AL; Naval Medical Research Center, Silver Spring, Maryland, United States of America.; Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
المصدر: PloS one [PLoS One] 2019 Aug 30; Vol. 14 (8), pp. e0221588. Date of Electronic Publication: 2019 Aug 30 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Antigens, Bacterial/*genetics , Bacterial Proteins/*genetics , Orientia tsutsugamushi/*genetics , Scrub Typhus/*microbiology, Antigens, Bacterial/chemistry ; Antigens, Bacterial/immunology ; Bacterial Proteins/chemistry ; Bacterial Proteins/immunology ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Molecular Typing ; Molecular Weight ; Orientia tsutsugamushi/classification ; Orientia tsutsugamushi/immunology ; Phylogeny ; Phylogeography ; Prevalence ; Scrub Typhus/diagnosis ; Scrub Typhus/epidemiology ; Scrub Typhus/immunology ; Sequence Analysis, DNA ; Severity of Illness Index ; Vietnam
مستخلص: Scrub typhus has been documented since 1932 in Vietnam, however, the disease burden of scrub typhus remains poorly understood in the country. We conducted this study to describe the phylogenetic analysis of the 56-kDa type-specific antigen (TSA) gene of Orientia tsutsugamushi associated with PCR positive cases of scrub typhus. Of 116 positive samples, 65 type-specific antigen gene sequences were obtained and classified into 3 genogroups: Karp, Kato and Gilliam. The Karp genogroup was the most frequently detected phylogenetic cluster in the study with 30 samples (46%), followed by Kato and Gilliam with 20 (31%) and 15 (23%), respectively. All sequences showed 94-100% nucleotide similarity to reference sequences collected in the central part of Vietnam in 2017. Patients infected with Karp genogroup were more likely to have significant thrombocytopenia than the other genogroups. These results suggest that any scrub typhus vaccine considered for use in Vietnam should provide protection against each of these 3 genogroups.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; 106680/Z/14/Z United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Antigens, Bacterial)
0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20190831 Date Completed: 20200311 Latest Revision: 20210110
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6716651
DOI: 10.1371/journal.pone.0221588
PMID: 31469878
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0221588