دورية أكاديمية
أعرض في EDS

Akinetic mutism and status epilepticus due to Epstein Barr virus encephalitis.

التفاصيل البيبلوغرافية
العنوان: Akinetic mutism and status epilepticus due to Epstein Barr virus encephalitis.
المؤلفون: Rodrigo-Armenteros P; Departments of Neurology, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Kapetanovic-García S; Departments of Neurology, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Antón-Méndez L; Radiology, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Gómez-Muga JJ; Radiology, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Río EB; Anesthesiology-Intensive Care, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Fernández-Cuesta MÁ; Neuropediatrics, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., García-Moncó JC; Departments of Neurology, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain. Electronic address: hospit05@sarenet.es.
المصدر: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2019 Oct; Vol. 185, pp. 105492. Date of Electronic Publication: 2019 Aug 19.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6968 (Electronic) Linking ISSN: 03038467 NLM ISO Abbreviation: Clin Neurol Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Assen, Van Gorcum.
مواضيع طبية MeSH: Akinetic Mutism/*physiopathology , Basal Ganglia Diseases/*physiopathology , Encephalitis, Viral/*physiopathology , Epstein-Barr Virus Infections/*physiopathology , Status Epilepticus/*physiopathology, Adolescent ; Akinetic Mutism/diagnostic imaging ; Akinetic Mutism/immunology ; Akinetic Mutism/therapy ; Anticonvulsants/therapeutic use ; Autoantibodies/immunology ; Basal Ganglia Diseases/diagnostic imaging ; Basal Ganglia Diseases/immunology ; Basal Ganglia Diseases/therapy ; Brain Edema/diagnostic imaging ; Brain Edema/immunology ; Brain Edema/physiopathology ; Brain Edema/therapy ; Chromonar ; Electroencephalography ; Encephalitis, Viral/diagnosis ; Encephalitis, Viral/immunology ; Encephalitis, Viral/therapy ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/therapy ; Glucocorticoids/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Male ; Methylprednisolone/therapeutic use ; Receptors, Dopamine D2/immunology ; Recovery of Function ; Status Epilepticus/immunology ; Status Epilepticus/therapy
مستخلص: Neurological complications of Epstein Barr virus (EBV) infection are infrequent and may include occasionally encephalitis, usually with a benign evolution. We here report on an aggressive case of EBV encephalitis in a 14-year-old boy with extensive basal ganglia involvement, and to a lesser degree of brain cortex who presented atypically with akinetic mutism and non-convulsive status epilepticus, requiring intensive care but showed a favorable outcome. EBV encephalitis is uncommon and its best management is unclear. Its pathophysiology is not well understood but could include autoimmunity. Onconeuronal and synaptic antibodies were negative in serum and cerebrospinal fluid, including the dopamine D2 receptor. To the best of our knowledge, this is the first report to evaluate antibodies to D2 receptors in EBV encephalitis. Corticosteroid therapy is usually recommended but the use of acyclovir is controversial. Intensive care is required in severe cases to assure a favorable outcome.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Akinetic mutism; Basal ganglia encephalitis; Encephalitis; Epstein Barr virus; Status epilepticus
المشرفين على المادة: 0 (Anticonvulsants)
0 (Autoantibodies)
0 (Glucocorticoids)
0 (Receptors, Dopamine D2)
R0C9NIE5JJ (Chromonar)
X4W7ZR7023 (Methylprednisolone)
تواريخ الأحداث: Date Created: 20190831 Date Completed: 20201029 Latest Revision: 20201029
رمز التحديث: 20221213
DOI: 10.1016/j.clineuro.2019.105492
PMID: 31470359
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6968
DOI:10.1016/j.clineuro.2019.105492