دورية أكاديمية
Hypogonadism in Pediatric Health: Adult Medicine Concepts Fail.
| العنوان: | Hypogonadism in Pediatric Health: Adult Medicine Concepts Fail. |
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| المؤلفون: | Grinspon RP; Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Gallo 1330 - C1425EFD Buenos Aires, Argentina., Freire AV; Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Gallo 1330 - C1425EFD Buenos Aires, Argentina., Rey RA; Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Gallo 1330 - C1425EFD Buenos Aires, Argentina. Electronic address: rodolforey@cedie.org.ar. |
| المصدر: | Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2019 Dec; Vol. 30 (12), pp. 879-890. Date of Electronic Publication: 2019 Aug 27. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9001516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3061 (Electronic) Linking ISSN: 10432760 NLM ISO Abbreviation: Trends Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier Science Pub. Co., [c1989- |
| مواضيع طبية MeSH: | Genitalia/*physiopathology , Hypogonadism/*physiopathology, Androgens/blood ; Anti-Mullerian Hormone/blood ; Female ; Genitalia/metabolism ; Gonadotropins/blood ; Humans ; Hypogonadism/blood ; Male ; Pediatrics/methods ; Pregnancy ; Primary Ovarian Insufficiency/blood ; Primary Ovarian Insufficiency/physiopathology ; Testosterone/blood |
| مستخلص: | The classical definition of hypogonadism, used in adult medicine, as gonadal failure resulting in deficient steroid and gamete production, and its classification into hypergonadotropic and hypogonadotropic refer to primary gonadal and hypothalamic-pituitary disorders respectively and may lead to under- or misdiagnosis in pediatrics. Indeed, in children with primary gonadal failure, gonadotropin levels may be within the reference range for age. Conversely, since gonadotropins and steroids are normally low during childhood, it may prove impossible to show the existence of a hypogonadotropic state before pubertal age. Anti-Müllerian hormone (AMH) and inhibin B arise as more adequate biomarkers to assess gonadal function and increase the possibility of making an earlier diagnosis of hypogonadism in children, which may positively impact on timely management. (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: androgens; anti-Müllerian hormone; inhibin; ovarian failure; ovarian insufficiency; testosterone |
| المشرفين على المادة: | 0 (Androgens) 0 (Gonadotropins) 3XMK78S47O (Testosterone) 80497-65-0 (Anti-Mullerian Hormone) |
| تواريخ الأحداث: | Date Created: 20190901 Date Completed: 20200824 Latest Revision: 20200824 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.tem.2019.08.002 |
| PMID: | 31471249 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-3061 |
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| DOI: | 10.1016/j.tem.2019.08.002 |