دورية أكاديمية
Prevalence and Predictors of Cisplatin-Induced Peripheral Neuropathy at the Kenyatta National Hospital.
| العنوان: | Prevalence and Predictors of Cisplatin-Induced Peripheral Neuropathy at the Kenyatta National Hospital. |
|---|---|
| المؤلفون: | Ezzi MS; University of Nairobi, Nairobi, Kenya., Othieno-Abinya NA; University of Nairobi, Nairobi, Kenya., Amayo E; University of Nairobi, Nairobi, Kenya., Oyiro P; University of Nairobi, Nairobi, Kenya., McLigeyo A; University of Nairobi, Nairobi, Kenya., Yatich RB; Moi Teaching and Referral Hospital, Eldoret, Kenya., Shoba B; University of KwaZulu-Natal, KwaZulu-Natal, South Africa. |
| المصدر: | Journal of global oncology [J Glob Oncol] 2019 Sep; Vol. 5, pp. 1-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101674751 Publication Model: Print Cited Medium: Internet ISSN: 2378-9506 (Electronic) Linking ISSN: 23789506 NLM ISO Abbreviation: J Glob Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Alexandria, VA : American Society of Clinical Oncology, [2015]-[2019] |
| مواضيع طبية MeSH: | Cisplatin/*therapeutic use , Peripheral Nervous System Diseases/*chemically induced, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cisplatin/pharmacology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Young Adult |
| مستخلص: | Purpose: To determine the prevalence, predictors, and/or risk factors of chemotherapy-induced peripheral neuropathy in patients undergoing chemotherapy with cisplatin at Kenyatta National Hospital, Nairobi, Kenya. Methods: This was a cross-sectional analysis of patients who underwent chemotherapy with cisplatin for at least 2 months at Kenyatta National Hospital oncology units. Peripheral neuropathy was determined by history and physical examination per the protocol. Data are presented in tables. Descriptive inferential statistics such as means, medians, and proportions were determined where applicable. Results: We recruited 67 patients who were undergoing chemotherapy with cisplatin. Fifty-six patients (83.6%) had peripheral neuropathy. Forty-five patients (81%) had mild-grade (grades 1 and 2) peripheral neuropathy. Only two patients (3.1%) had grade 4 neuropathy. Almost all patients who were overweight or obese developed peripheral neuropathy. Conclusion: Peripheral neuropathy among patients receiving cisplatin is quite prevalent at Kenyatta National Hospital (83.6% prevalence rate). However, most of the patients had a mild grade of neuropathy, which is largely consistent with literature elsewhere. |
| References: | Pain. 2014 Dec;155(12):2461-70. (PMID: 25261162) Expert Opin Drug Saf. 2011 May;10(3):407-17. (PMID: 21210753) Ann Oncol. 2004 Sep;15(9):1439-42. (PMID: 15319252) J Clin Oncol. 2016 Sep 1;34(25):3014-22. (PMID: 27325863) JAMA Neurol. 2018 Aug 1;75(8):980-988. (PMID: 29799906) Drug Saf. 2009;32(12):1109-22. (PMID: 19916578) J Peripher Nerv Syst. 2007 Sep;12(3):210-5. (PMID: 17868248) J Clin Oncol. 1995 Feb;13(2):490-6. (PMID: 7844610) Chemother Res Pract. 2012;2012:913848. (PMID: 22482054) Ann Oncol. 1999 Jun;10(6):693-700. (PMID: 10442192) J Clin Oncol. 1996 Jul;14(7):2101-12. (PMID: 8683243) J Clin Oncol. 1995 Jan;13(1):26-32. (PMID: 7799029) J Clin Oncol. 2013 Jul 20;31(21):2699-707. (PMID: 23775951) J Clin Oncol. 2014 Jun 20;32(18):1941-67. (PMID: 24733808) Ir J Med Sci. 2014 Mar;183(1):53-8. (PMID: 23832573) N Engl J Med. 1990 Jan 11;322(2):89-94. (PMID: 2152972) Curr Oncol. 2014 Aug;21(4):174-80. (PMID: 25089099) Support Care Cancer. 2014 Aug;22(8):2261-9. (PMID: 24789421) Neurology. 2010 Mar 2;74(9):762-6. (PMID: 20194916) Crit Rev Oncol Hematol. 2012 Apr;82(1):51-77. (PMID: 21908200) J Clin Oncol. 2003 Mar 1;21(5):927-31. (PMID: 12610195) Br J Cancer. 2001 Sep 14;85(6):823-6. (PMID: 11556831) Support Care Cancer. 2006 Mar;14(3):223-9. (PMID: 16021477) |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 20190904 Date Completed: 20200407 Latest Revision: 20200408 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6733204 |
| DOI: | 10.1200/JGO.19.00097 |
| PMID: | 31479343 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2378-9506 |
|---|---|
| DOI: | 10.1200/JGO.19.00097 |