دورية أكاديمية
أعرض في EDS

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.

التفاصيل البيبلوغرافية
العنوان: The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.
المؤلفون: de Castro-Jorge LA; Department of Cell Biology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., de Carvalho RVH; Department of Cell Biology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Klein TM; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Hiroki CH; Center for Research in Inflammatory Diseases, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Lopes AH; Center for Research in Inflammatory Diseases, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Guimarães RM; Center for Research in Inflammatory Diseases, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Fumagalli MJ; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Floriano VG; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Agostinho MR; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Slhessarenko RD; School of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., Ramalho FS; Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Cunha TM; Center for Research in Inflammatory Diseases, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Cunha FQ; Center for Research in Inflammatory Diseases, Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., da Fonseca BAL; Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil., Zamboni DS; Department of Cell Biology, School of Medicine of Ribeirão Preto, University of São Paulo. Ribeirão Preto, Brazil.
المصدر: PLoS pathogens [PLoS Pathog] 2019 Sep 03; Vol. 15 (9), pp. e1007934. Date of Electronic Publication: 2019 Sep 03 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Alphavirus Infections/*immunology , Inflammasomes/*metabolism , NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism, Adult ; Aged ; Alphavirus Infections/metabolism ; Animals ; Carrier Proteins/metabolism ; Caspase 1/metabolism ; Chikungunya virus/metabolism ; Dengue Virus/metabolism ; Disease Models, Animal ; Female ; Humans ; Inflammasomes/immunology ; Inflammation/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Reactive Oxygen Species/metabolism ; Togaviridae/pathogenicity ; Zika Virus/metabolism
مستخلص: Mayaro virus (MAYV) is an arbovirus that circulates in Latin America and is emerging as a potential threat to public health. Infected individuals develop Mayaro fever, a severe inflammatory disease characterized by high fever, rash, arthralgia, myalgia and headache. The disease is often associated with a prolonged arthralgia mediated by a chronic inflammation that can last months. Although the immune response against other arboviruses, such as chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV), has been extensively studied, little is known about the pathogenesis of MAYV infection. In this study, we established models of MAYV infection in macrophages and in mice and found that MAYV can replicate in bone marrow-derived macrophages and robustly induce expression of inflammasome proteins, such as NLRP3, ASC, AIM2, and Caspase-1 (CASP1). Infection performed in macrophages derived from Nlrp3-/-, Aim2-/-, Asc-/-and Casp1/11-/-mice indicate that the NLRP3, but not AIM2 inflammasome is essential for production of inflammatory cytokines, such as IL-1β. We also determined that MAYV triggers NLRP3 inflammasome activation by inducing reactive oxygen species (ROS) and potassium efflux. In vivo infections performed in inflammasome-deficient mice indicate that NLRP3 is involved with footpad swelling, inflammation and pain, establishing a role of the NLRP3 inflammasome in the MAYV pathogenesis. Accordingly, we detected higher levels of caspase1-p20, IL-1β and IL-18 in the serum of MAYV-infected patients as compared to healthy individuals, supporting the participation of the NLRP3-inflammasome during MAYV infection in humans.
Competing Interests: The authors have declared that no competing interests exist.
References: Cold Spring Harb Perspect Biol. 2014 Nov 13;7(3):a016253. (PMID: 25395297)
Front Microbiol. 2015 Sep 01;6:895. (PMID: 26388848)
PLoS Negl Trop Dis. 2014 Aug 07;8(8):e2969. (PMID: 25101995)
South Med J. 2005 Apr;98(4):484-5. (PMID: 15898531)
Science. 1995 Mar 31;267(5206):2000-3. (PMID: 7535475)
Sci Rep. 2017 Jul 19;7(1):5845. (PMID: 28724943)
PLoS Pathog. 2012;8(8):e1002857. (PMID: 22916014)
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6. (PMID: 20457908)
Am J Pathol. 2011 Jan;178(1):32-40. (PMID: 21224040)
Acta Trop. 2019 Feb;190:395-402. (PMID: 30552880)
Am J Trop Med Hyg. 2011 Oct;85(4):750-7. (PMID: 21976583)
PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004104. (PMID: 26496497)
J Virol. 2011 May;85(9):4167-72. (PMID: 21289120)
J Clin Microbiol. 2019 Apr 26;57(5):. (PMID: 30787146)
Nat Commun. 2018 Jan 9;9(1):106. (PMID: 29317641)
Sci Rep. 2017 Aug 18;7(1):8718. (PMID: 28821712)
J Exp Med. 2006 Jun 12;203(6):1407-12. (PMID: 16717117)
J Infect Dis. 2018 May 25;217(12):1942-1951. (PMID: 29518228)
J Leukoc Biol. 2019 Sep;106(3):631-640. (PMID: 31063608)
Nat Microbiol. 2017 Oct;2(10):1435-1445. (PMID: 28848230)
PLoS Pathog. 2017 Jan 6;13(1):e1006123. (PMID: 28060938)
J Virol. 2014 Jun;88(12):6862-72. (PMID: 24696480)
Sci Rep. 2016 Jun 10;6:27912. (PMID: 27283237)
Cell. 2015 Nov 19;163(5):1095-1107. (PMID: 26553503)
Virol J. 2018 Jul 24;15(1):112. (PMID: 30041676)
PLoS Pathog. 2011 Sep;7(9):e1002268. (PMID: 21966274)
Semin Immunopathol. 2017 Jul;39(5):563-574. (PMID: 28401256)
Immunity. 2009 Apr 17;30(4):556-65. (PMID: 19362020)
Immunity. 2006 Mar;24(3):317-27. (PMID: 16546100)
PLoS Pathog. 2013;9(5):e1003392. (PMID: 23737748)
Nature. 2006 Mar 9;440(7081):228-32. (PMID: 16407890)
Cytokine. 2015 Dec;76(2):545-548. (PMID: 26239414)
Cell Rep. 2017 Feb 28;18(9):2077-2087. (PMID: 28249154)
J Wildl Dis. 2016 Oct;52(4):883-892. (PMID: 27479900)
Mol Pain. 2017 Jan-Dec;13:1744806917719804. (PMID: 28714351)
Nat Rev Immunol. 2013 Jun;13(6):453-60. (PMID: 23681101)
Infect Genet Evol. 2015 Jun;32:401-8. (PMID: 25847693)
Immunity. 2009 Jun 19;30(6):875-87. (PMID: 19501000)
Sci Rep. 2016 May 27;6:26955. (PMID: 27230787)
Nat Immunol. 2010 May;11(5):395-402. (PMID: 20351692)
Viruses. 2019 Jan 31;11(2):. (PMID: 30709036)
PLoS Negl Trop Dis. 2017 Aug 31;11(8):e0005462. (PMID: 28859086)
Nature. 2009 Mar 26;458(7237):514-8. (PMID: 19158675)
J Gen Virol. 2018 Jun;99(6):761-762. (PMID: 29745869)
Immunity. 2009 Apr 17;30(4):566-75. (PMID: 19362023)
Nat Med. 2015 Jul;21(7):677-87. (PMID: 26121197)
J Exp Med. 2009 Jan 16;206(1):79-87. (PMID: 19139171)
Emerg Infect Dis. 2015 Oct;21(10):1742-50. (PMID: 26401714)
J Infect Dis. 2016 Dec 15;214(suppl 5):S482-S487. (PMID: 27920178)
Genome Announc. 2016 Mar 03;4(2):. (PMID: 26941134)
BMC Bioinformatics. 2007 Apr 20;8:131. (PMID: 17445280)
Am J Trop Med Hyg. 2015 Feb;92(2):401-4. (PMID: 25510721)
Braz J Med Biol Res. 2004 Mar;37(3):401-7. (PMID: 15060710)
Biomol Detect Quantif. 2014 Sep 06;1(1):23-33. (PMID: 27920994)
Mol Cell. 2002 Aug;10(2):417-26. (PMID: 12191486)
Cell Rep. 2019 Jan 8;26(2):429-437.e5. (PMID: 30625325)
Am J Trop Med Hyg. 1983 Jul;32(4):854-61. (PMID: 6309027)
Immunity. 2016 Jun 21;44(6):1455-69. (PMID: 27332734)
Emerg Infect Dis. 2016 Nov;22(11):2000-2002. (PMID: 27767924)
Am J Trop Med Hyg. 1981 May;30(3):674-81. (PMID: 6266263)
Genome Announc. 2015 Dec 17;3(6):. (PMID: 26679574)
J Virol Methods. 2013 Jan;187(1):185-9. (PMID: 23085307)
Science. 2013 Sep 13;341(6151):1250-3. (PMID: 24031018)
Curr Opin Virol. 2015 Jun;12:38-46. (PMID: 25771504)
J Virol. 2015 Aug;89(15):7955-69. (PMID: 25995257)
Nat Rev Immunol. 2016 Jul;16(7):407-20. (PMID: 27291964)
PLoS One. 2010 Dec 17;5(12):e15263. (PMID: 21179419)
J Immunol. 2017 Sep 15;199(6):2055-2068. (PMID: 28784846)
Sci Rep. 2017 Nov 22;7(1):16050. (PMID: 29167459)
Cell. 2016 May 5;165(4):792-800. (PMID: 27153493)
Nat Med. 2013 Jul;19(7):909-15. (PMID: 23749230)
المشرفين على المادة: 0 (Carrier Proteins)
0 (Inflammasomes)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Nlrp3 protein, mouse)
0 (Reactive Oxygen Species)
EC 3.4.22.36 (Caspase 1)
تواريخ الأحداث: Date Created: 20190904 Date Completed: 20200207 Latest Revision: 20200309
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6743794
DOI: 10.1371/journal.ppat.1007934
PMID: 31479495
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1007934