دورية أكاديمية
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Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375.

التفاصيل البيبلوغرافية
العنوان: Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375.
المؤلفون: Guo QF; Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China. guoqf.2008@163.com., Yin ZH; Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China. yinzhenhua1000@126.com., Zhang JJ; Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China. zhangjuan8908@163.com., Kang WY; Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China. Kangweny@hotmail.com., Wang XW; Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China. wangxw@im.ac.cn., Ding G; Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Union Medical College, Beijing 100193, China. gding@implad.ac.cn., Chen L; Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China. lchenchina@163.com.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2019 Sep 05; Vol. 24 (18). Date of Electronic Publication: 2019 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Soil Microbiology*, Antineoplastic Agents/*pharmacology , Biological Products/*pharmacology , Chaetomium/*chemistry , Cytochalasins/*pharmacology, Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Biological Products/chemistry ; Biological Products/isolation & purification ; Cell Line ; Cytochalasins/chemistry ; Cytochalasins/isolation & purification ; Humans ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Spectrum Analysis
مستخلص: Two new cytochalasans, Chaetomadrasins A ( 1 ) and B ( 2 ), along with six known analogues ( 3 - 8 ), were isolated from the solid-state fermented culture of desert soil-derived Chaetomium madrasense 375. Their structures were clarified by comprehensive spectroscopic analyses, and the absolute configurations of Compounds 1 and 2 were confirmed by electronic circular dichroism (ECD) and calculated ECD. For the first time, Chaetomadrasins A (1), which belongs to the chaetoglobosin family, is characterized by the presence of all oxygen atoms in the form of Carbonyl. Chaetomadrasin B ( 2 ) represents the first example of chaetoglobosin type cytochalasan characterized by a hydroxy unit and carbonyl group fused to the indole ring. Compounds 1 and 2 displayed moderate cytotoxicity against HepG2 human hepatocellular carcinoma cells.
Competing Interests: The authors declare there is no competing financial interest.
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معلومات مُعتمدة: 31501552 the National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Chaetomium madrasense; cytochalasans; cytotoxicity; fungal alkaloids
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Biological Products)
0 (Cytochalasins)
تواريخ الأحداث: Date Created: 20190908 Date Completed: 20200127 Latest Revision: 20240720
رمز التحديث: 20240720
مُعرف محوري في PubMed: PMC6767004
DOI: 10.3390/molecules24183240
PMID: 31492021
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules24183240