دورية أكاديمية
Machine Learning Interpretation of Extended Human Papillomavirus Genotyping by Onclarity in an Asian Cervical Cancer Screening Population.
العنوان: | Machine Learning Interpretation of Extended Human Papillomavirus Genotyping by Onclarity in an Asian Cervical Cancer Screening Population. |
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المؤلفون: | Wong OGW; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China wonggw@pathology.hku.hk anycheun@pathology.hku.hk., Ng IFY; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Tsun OKL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Pang HH; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Ip PPC; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Cheung ANY; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China wonggw@pathology.hku.hk anycheun@pathology.hku.hk. |
المصدر: | Journal of clinical microbiology [J Clin Microbiol] 2019 Nov 22; Vol. 57 (12). Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2019). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology. |
مواضيع طبية MeSH: | Machine Learning*, Early Detection of Cancer/*methods , Genotyping Techniques/*methods , Papillomaviridae/*classification , Papillomavirus Infections/*diagnosis , Uterine Cervical Neoplasms/*diagnosis , Uterine Cervical Dysplasia/*diagnosis, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian People ; Female ; Genotype ; Humans ; Middle Aged ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Sensitivity and Specificity ; Uterine Cervical Neoplasms/virology ; Young Adult ; Uterine Cervical Dysplasia/virology |
مستخلص: | This study aimed (i) to compare the performance of the BD Onclarity human papillomavirus (HPV) assay with the Cobas HPV test in identifying cervical intraepithelial neoplasia 2/3 or above (CIN2/3+) in an Asian screening population and (ii) to explore improving the cervical cancer detection specificity of Onclarity by machine learning. We tested 605 stratified random archived samples of cervical liquid-based cytology samples with both assays. All samples had biopsy diagnosis or repeated negative cytology follow-up. Association rule mining (ARM) was employed to discover coinfection likely to give rise to CIN2/3+. Outcome classifiers interpreting the extended genotyping results of Onclarity were built with different underlying models. The sensitivities (Onclarity, 96.32%; Cobas, 95.71%) and specificities (Onclarity, 46.38%; Cobas, 45.25%) of the high-risk HPV (hrHPV) components of the two tests were not significantly different. When HPV16 and HPV18 were used to further interpret hrHPV-positive cases, Onclarity displayed significantly higher specificity (Onclarity, 87.10%; Cobas, 80.77%). Both hrHPV tests achieved the same sensitivities (Onclarity, 90.91%; Cobas, 90.91%) and similar specificities (Onclarity, 48.46%; Cobas, 51.98%) when used for triaging atypical squamous cells of undetermined significance. Positivity in both HPV16 and HPV33/58 of the Onclarity channels entails the highest probability of developing CIN2/3+. Incorporating other hrHPVs into the outcome classifiers improved the specificity of identifying CIN2/3 to up to 94.32%. The extended genotyping of Onclarity therefore can help to highlight patients having the highest risk of developing CIN2/3+, with the potential to reduce unnecessary colposcopy and negative psychosocial impact on women receiving the reports. (Copyright © 2019 American Society for Microbiology.) |
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فهرسة مساهمة: | Keywords: Cobas; HPV test; Onclarity; cervical cancer; primary screening |
تواريخ الأحداث: | Date Created: 20190913 Date Completed: 20200716 Latest Revision: 20221207 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6879281 |
DOI: | 10.1128/JCM.00997-19 |
PMID: | 31511337 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-660X |
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DOI: | 10.1128/JCM.00997-19 |