دورية أكاديمية
Machine Learning Interpretation of Extended Human Papillomavirus Genotyping by Onclarity in an Asian Cervical Cancer Screening Population.
| العنوان: | Machine Learning Interpretation of Extended Human Papillomavirus Genotyping by Onclarity in an Asian Cervical Cancer Screening Population. |
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| المؤلفون: | Wong OGW; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China wonggw@pathology.hku.hk anycheun@pathology.hku.hk., Ng IFY; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Tsun OKL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Pang HH; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Ip PPC; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Cheung ANY; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China wonggw@pathology.hku.hk anycheun@pathology.hku.hk. |
| المصدر: | Journal of clinical microbiology [J Clin Microbiol] 2019 Nov 22; Vol. 57 (12). Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology. |
| مواضيع طبية MeSH: | Machine Learning*, Early Detection of Cancer/*methods , Genotyping Techniques/*methods , Papillomaviridae/*classification , Papillomavirus Infections/*diagnosis , Uterine Cervical Neoplasms/*diagnosis , Uterine Cervical Dysplasia/*diagnosis, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian People ; Female ; Genotype ; Humans ; Middle Aged ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Sensitivity and Specificity ; Uterine Cervical Neoplasms/virology ; Young Adult ; Uterine Cervical Dysplasia/virology |
| مستخلص: | This study aimed (i) to compare the performance of the BD Onclarity human papillomavirus (HPV) assay with the Cobas HPV test in identifying cervical intraepithelial neoplasia 2/3 or above (CIN2/3+) in an Asian screening population and (ii) to explore improving the cervical cancer detection specificity of Onclarity by machine learning. We tested 605 stratified random archived samples of cervical liquid-based cytology samples with both assays. All samples had biopsy diagnosis or repeated negative cytology follow-up. Association rule mining (ARM) was employed to discover coinfection likely to give rise to CIN2/3+. Outcome classifiers interpreting the extended genotyping results of Onclarity were built with different underlying models. The sensitivities (Onclarity, 96.32%; Cobas, 95.71%) and specificities (Onclarity, 46.38%; Cobas, 45.25%) of the high-risk HPV (hrHPV) components of the two tests were not significantly different. When HPV16 and HPV18 were used to further interpret hrHPV-positive cases, Onclarity displayed significantly higher specificity (Onclarity, 87.10%; Cobas, 80.77%). Both hrHPV tests achieved the same sensitivities (Onclarity, 90.91%; Cobas, 90.91%) and similar specificities (Onclarity, 48.46%; Cobas, 51.98%) when used for triaging atypical squamous cells of undetermined significance. Positivity in both HPV16 and HPV33/58 of the Onclarity channels entails the highest probability of developing CIN2/3+. Incorporating other hrHPVs into the outcome classifiers improved the specificity of identifying CIN2/3 to up to 94.32%. The extended genotyping of Onclarity therefore can help to highlight patients having the highest risk of developing CIN2/3+, with the potential to reduce unnecessary colposcopy and negative psychosocial impact on women receiving the reports. (Copyright © 2019 American Society for Microbiology.) |
| References: | J Clin Microbiol. 2010 Mar;48(3):758-64. (PMID: 20042614) JAMA. 2018 Jul 3;320(1):43-52. (PMID: 29971397) PLoS One. 2014 Jan 20;9(1):e86835. (PMID: 24466262) JAMA. 2018 Aug 21;320(7):687-705. (PMID: 30140883) J Am Soc Cytopathol. 2019 Sep - Oct;8(5):284-292. (PMID: 31320315) J Infect Dis. 2011 Apr 1;203(7):910-20. (PMID: 21402543) Gynecol Oncol. 2015 Apr;137(1):47-54. (PMID: 25667973) J Clin Microbiol. 2012 May;50(5):1691-7. (PMID: 22337983) BMC Cancer. 2015 Dec 16;15:968. (PMID: 26674353) MMWR Morb Mortal Wkly Rep. 2012 Apr 20;61:258-61. (PMID: 22513527) Lancet Oncol. 2018 Dec;19(12):1569-1578. (PMID: 30392810) J Med Virol. 1999 Oct;59(2):232-8. (PMID: 10459162) Cell Biosci. 2012 May 09;2(1):17. (PMID: 22571619) J Clin Virol. 2012 May;54(1):61-5. (PMID: 22326759) PLoS One. 2017 Aug 22;12(8):e0182854. (PMID: 28829791) J Clin Microbiol. 2015 Jan;53(1):52-9. (PMID: 25339396) Gynecol Oncol. 2014 Sep;134(3):534-9. (PMID: 24979052) Cytopathology. 2018 Jun;29(3):267-274. (PMID: 29578257) J Clin Virol. 2011 Jun;51(2):136-8. (PMID: 21530385) Gynecol Oncol. 2015 Feb;136(2):189-97. (PMID: 25579108) J Clin Virol. 2016 Sep;82:145-151. (PMID: 27498250) J Clin Virol. 2018 Dec;109:13-18. (PMID: 30368218) Lancet Oncol. 2011 Sep;12(9):880-90. (PMID: 21865084) Am J Clin Pathol. 2014 Jul;142(1):43-50. (PMID: 24926084) Int J Cancer. 2013 Jun 1;132(11):2528-36. (PMID: 23136059) Acta Obstet Gynecol Scand. 2011 May;90(5):445-51. (PMID: 21306349) Diagn Cytopathol. 2018 Dec;46(12):987-992. (PMID: 30284405) J Obstet Gynaecol Res. 2014 Feb;40(2):561-9. (PMID: 24147758) |
| فهرسة مساهمة: | Keywords: Cobas; HPV test; Onclarity; cervical cancer; primary screening |
| تواريخ الأحداث: | Date Created: 20190913 Date Completed: 20200716 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6879281 |
| DOI: | 10.1128/JCM.00997-19 |
| PMID: | 31511337 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-660X |
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| DOI: | 10.1128/JCM.00997-19 |