دورية أكاديمية
Preparation of pentagamaboronon-0 and its fructose and sorbitol complexes as boron carrier for boron neutron capture therapy (BNCT) application.
| العنوان: | Preparation of pentagamaboronon-0 and its fructose and sorbitol complexes as boron carrier for boron neutron capture therapy (BNCT) application. |
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| المؤلفون: | Susidarti RA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281.; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281., Utomo RY; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281.; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281., Qodria L; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281., Ramadani RD; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281., Ohta Y; Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka, Japan., Hattori Y; Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka, Japan., Kirihata M; Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka, Japan., Meiyanto E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281.; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281. |
| المصدر: | Research in pharmaceutical sciences [Res Pharm Sci] 2019 Aug; Vol. 14 (4), pp. 286-292. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences and Health Services Country of Publication: Iran NLM ID: 101516968 Publication Model: Print Cited Medium: Print ISSN: 1735-5362 (Print) Linking ISSN: 17355362 NLM ISO Abbreviation: Res Pharm Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Isfahan : School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences and Health Services |
| مستخلص: | Development of specific and selective boron carriers is indispensable for boron neutron capture therapy (BNCT) application. Pentagamaboronon-0 (PGB-0) is a promising candidate as boron carrier compound due to the low but selective cytotoxicity in breast cancer cells. Formerly we reported synthesis of PGB-0 which was ineffective due to its low aqueous solubility. In the present study, we, therefore, introduced the new PGB-0 preparation complexed with sugars to increase its solubility in water. By synthesizing at room temperature and using flash chromatography for the purification, we produced PGB-0 with a yield of 40%. PGB-0 fructose complex (PGB-0-F) and PGB-0 sorbitol complex (PGB-0-Sor) were obtained with smaller particle size compared to PGB-0 suspension in water. Based on the MTT assay, the cytotoxicity of PGB-0-F and PGB-0-Sor were higher than PGB-0 even though still categorized as low cytotoxic agents. In conclusion, we provided PGB-0 with a new method and improved its solubility in water. Further investigations are still needed to develop more efficient PGB-0 as boron carrier for BNCT in various cancers. |
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| فهرسة مساهمة: | Keywords: BNCT; Boron carrier; Fructose and sorbitol complexes; PGB-0. |
| تواريخ الأحداث: | Date Created: 20190914 Latest Revision: 20201001 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6714113 |
| DOI: | 10.4103/1735-5362.263552 |
| PMID: | 31516505 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1735-5362 |
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| DOI: | 10.4103/1735-5362.263552 |