دورية أكاديمية
أعرض في EDS

Association of circulating exosomal miR-122 levels with BAT activity in healthy humans.

التفاصيل البيبلوغرافية
العنوان: Association of circulating exosomal miR-122 levels with BAT activity in healthy humans.
المؤلفون: Okamatsu-Ogura Y; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan. y-okamatsu@vetmed.hokudai.ac.jp., Matsushita M; Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, 065-0013, Japan., Bariuan JV; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan., Nagaya K; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan., Tsubota A; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan., Saito M; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.
المصدر: Scientific reports [Sci Rep] 2019 Sep 13; Vol. 9 (1), pp. 13243. Date of Electronic Publication: 2019 Sep 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Body Mass Index*, Adipose Tissue, Brown/*pathology , Exosomes/*metabolism , MicroRNAs/*blood, Adipose Tissue, Brown/diagnostic imaging ; Adipose Tissue, Brown/metabolism ; Adult ; Energy Metabolism ; Fluorodeoxyglucose F18/metabolism ; Healthy Volunteers ; Humans ; Male ; Positron-Emission Tomography ; Tomography, X-Ray Computed
مستخلص: Brown adipose tissue (BAT) plays an important role in body fat accumulation and the regulation of energy expenditure. Since the role of miRNAs in the pathogenesis of obesity and related metabolic diseases is contentious, we analyzed exosomal miRNAs in serum of healthy subjects with special references to BAT activity and body fat level. Forty male volunteers aged 20-30 years were recruited. Their BAT activity was assessed by fluorodeoxyglucose positron emission tomography and computed tomography after 2 h of cold exposure and expressed as a maximal standardized uptake value (SUVmax). Exosomal miRNA levels was analyzed using microarray and real-time PCR analyses. The miR-122-5p level in the high BAT activity group (SUV ≧ 3) was 53% lower than in the low BAT activity group (SUVmax <3). Pearson's correlation analysis revealed that the serum miR-122-5p level correlated negatively with BAT activity and the serum HDL-cholesterol, and it correlated positively with age, BMI, body fat mass, and total cholesterol and triglyceride serum levels. Multivariate regression analysis revealed that BAT activity was associated with the serum miR-122-5p level independently of the other parameters. These results reveal the serum exosomal miR-122-5p level is negatively associated with BAT activity independently of obesity.
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المشرفين على المادة: 0 (MIRN122 microRNA, human)
0 (MicroRNAs)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
تواريخ الأحداث: Date Created: 20190915 Date Completed: 20201030 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6744505
DOI: 10.1038/s41598-019-49754-1
PMID: 31519959
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-49754-1