دورية أكاديمية
Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.
| العنوان: | Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults. |
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| المؤلفون: | Camargos EF; Universidade de Brasília (UnB) Brasília, DF, Brazil., Goncalves ID; Universidade de Brasília (UnB) Brasília, DF, Brazil., Bretones LA; Universidade de Brasília (UnB) Brasília, DF, Brazil., Machado MF; Universidade de Brasília (UnB) Brasília, DF, Brazil., Morais-Junior GS; Universidade de Brasília (UnB) Brasília, DF, Brazil., Brito AF; Secretaria de Estado da Saúde (SES) Brasília, DF, Brazil., Henriques AD; Universidade de Brasília (UnB) Brasília, DF, Brazil., Morais CF; Universidade de Brasília (UnB) Brasília, DF, Brazil.; Universidade Católica de Brasília (UCB-DF) Brasília, DF, Brazil., Nóbrega OT; Universidade de Brasília (UnB) Brasília, DF, Brazil. |
| المصدر: | International journal of molecular epidemiology and genetics [Int J Mol Epidemiol Genet] 2019 Aug 15; Vol. 10 (4), pp. 59-66. Date of Electronic Publication: 2019 Aug 15 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101525762 Publication Model: eCollection Cited Medium: Print ISSN: 1948-1756 (Print) Linking ISSN: 19481756 NLM ISO Abbreviation: Int J Mol Epidemiol Genet Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Madison, Wis. : e-Century Pub. Corp. |
| مستخلص: | This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders. Genotyping of classic polymorphic sites for the ApoE (rs429358 and rs7412) and the ACE (rs4646994) genes used peripheral DNA. A total of 63% of the subjects reported poor quality of sleep assessed by the PSQI whereas 54 (33%) reported daytime sleepiness through the Epworth scale. A significant correlation was observed between APOE and PSQI, with a greater frequency of the poor nighttime sleep quality phenotype among ε2 carriers, whereas no correlation was found among any of the sleep scores and the ACE genotypes. Thus, we suggest a correlation between APOE alleles and scale-assessed sleep quality scores in older adults, with no implications for ACE alleles, in a context devoid of cognitive impairment. Competing Interests: None. |
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| فهرسة مساهمة: | Keywords: Apolipoprotein; cognition disorders; genotyping; older adults; sleep |
| تواريخ الأحداث: | Date Created: 20190917 Latest Revision: 20201001 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6737399 |
| PMID: | 31523375 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-1756 |
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