دورية أكاديمية
أعرض في EDS

The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study.

التفاصيل البيبلوغرافية
العنوان: The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study.
المؤلفون: Ominato J; Division of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Oyama T; Division of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.; Uonuma Eye Clinic, Uonuma, Japan., Cho H; Division of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Shiozaki N; Division of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Umezu H; Department of Pathology, Niigata University Medical and Dental Hospital, Niigata, Japan., Takizawa J; Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan., Fukuchi T; Division of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
المصدر: BMJ open ophthalmology [BMJ Open Ophthalmol] 2019 Aug 09; Vol. 4 (1), pp. e000295. Date of Electronic Publication: 2019 Aug 09 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101714806 Publication Model: eCollection Cited Medium: Internet ISSN: 2397-3269 (Electronic) Linking ISSN: 23973269 NLM ISO Abbreviation: BMJ Open Ophthalmol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd., [2017]-
مستخلص: Objective: This study aimed to examine the natural course and relapse rate of IgG4-related ophthalmic disease (IgG4-ROD) after debulking surgery in Japanese patients.
Methods and Analysis: This retrospective review included patients with IgG4-ROD who did not undergo further treatment following debulking surgery. The patients were diagnosed between January 2009 and December 2018 at the Department of Ophthalmology and Pathology, Niigata University Medical and Dental Hospital. The main outcome measures included postoperative IgG4-ROD recurrence rate and differences between patients with and without recurrent disease.
Results: Fifteen patients (six male, 9 female; 61.8±16.2 years) were included. Twelve patients (80.0%) had dacryoadenitis disease and three patients (20.0%) had orbital fat tissue disease. About 70%-100% of the lesion was resected in the debulking surgery and the pathological diagnosis was rendered. A definitive diagnosis was made in 13 cases (86.7%) and a probable diagnosis in 2 cases (13.3%). Patients were followed up for 39.0±25.5 months following operation. All patients had lesion volume reduction and patients with dacryoadenitis had eyelid swelling improvement after surgery. Two patients (13.3%) had disease recurrence and six patients (40.0%) had extraophthalmic lesions. There was no statistically significant difference in clinical features between relapsed and non-recurring cases.
Conclusion: We observed a 13.3% relapse rate following debulking surgery in patients with IgG4-ROD who did not undergo further treatment. This rate is lower than the documented relapse rate of 30%-70% following oral prednisolone therapy. Therefore, debulking surgery may be a treatment option for IgG4-ROD.
Competing Interests: Competing interests: None declared.
التعليقات: Comment in: BMJ Open Ophthalmol. 2019 Oct 18;4(1):e000401. (PMID: 31750397)
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فهرسة مساهمة: Keywords: debulking surgery; igg4-related ophthalmic disease; relapse rate
تواريخ الأحداث: Date Created: 20190917 Latest Revision: 20220410
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6711462
DOI: 10.1136/bmjophth-2019-000295
PMID: 31523717
قاعدة البيانات: MEDLINE
الوصف
تدمد:2397-3269
DOI:10.1136/bmjophth-2019-000295