دورية أكاديمية
Role of preoperative pregabalin in reducing inhalational anesthetic requirements in abdominal hysterectomy: randomized controlled trial.
| العنوان: | Role of preoperative pregabalin in reducing inhalational anesthetic requirements in abdominal hysterectomy: randomized controlled trial. |
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| المؤلفون: | El-Refai NA; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt - nesrinerefai@hotmail.com., Shehata JH; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Lotfy A; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Elbadawy AM; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdel Rahman RA; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Gamaleldin TM; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Dobal NM; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Mohamed AA; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Farrag TA; Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt., Shafik YM; Department of Anesthesia, Egyptian Medical Military Academy, Cairo, Egypt., Kamal AF; Department of Anesthesia, Students' Educational Hospital, Cairo, Egypt. |
| المصدر: | Minerva anestesiologica [Minerva Anestesiol] 2020 Jan; Vol. 86 (1), pp. 56-63. Date of Electronic Publication: 2019 Sep 13. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: [Edizioni Minerva Medica] Country of Publication: Italy NLM ID: 0375272 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1827-1596 (Electronic) Linking ISSN: 03759393 NLM ISO Abbreviation: Minerva Anestesiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Torino, [Edizioni Minerva Medica] |
| مواضيع طبية MeSH: | Anesthesia, Inhalation*, Analgesics/*therapeutic use , Anesthetics, Inhalation/*administration & dosage , Hysterectomy/*methods , Pregabalin/*therapeutic use, Adult ; Consciousness Monitors ; Double-Blind Method ; Female ; Hemodynamics/drug effects ; Humans ; Isoflurane/administration & dosage ; Middle Aged ; Pain Measurement ; Pain, Postoperative/epidemiology ; Postoperative Nausea and Vomiting/epidemiology ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Background: Preoperative oral pregabalin controls postoperative pain and decreases anesthetic requirements in total intravenous anesthesia. In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. Methods: We investigated the effectiveness of preoperative oral pregabalin 150 mg in women undergoing elective open total abdominal hysterectomy under general anesthesia. A prospective, randomized, double-blind, controlled study was conducted in a university hospital. The study included 50 women (18-60 yrs.), ASA I or II, admitted for abdominal hysterectomy under general anesthesia. Exclusion criteria were allergy to pregabalin; calcium channel blockers, antiepileptic drugs, antidepressant drugs, any analgesics, sedatives, or oral hypoglycemic agents. Patients were randomized into two groups; Pregabalin group received oral pregabalin 150 mg and placebo group. Main outcome measures was inhaled isoflurane requirements to maintain hemodynamics ±20% of baseline and bispectral index of 40 - 60, measured using MAQUET Flow-I anesthetic machine. Secondary outcomes were attenuation of pressor response to intubation, postoperative pain, and first time for rescue analgesia, total analgesics and adverse effects. Results: Isoflurane consumption was significantly less in pregabalin group (7.80±1.27 mL h -1) versus (12.27±2.49 mL h-1) in the control group, (P=0.00). Better hemodynamic stability was in pregabalin group. First postoperative hour: the mean VAS Score was significantly higher in control group (7.10±1.20) compared to pregabalin group (4.50±1.70), P<0.001. More dizziness was in pregabalin group. Conclusions: Preoperative pregabalin 150 mg, 1 h before total abdominal hysterectomy has an inhaled anesthetic-sparing effect, maintain hemodynamics and optimizes postoperative analgesia. |
| المشرفين على المادة: | 0 (Analgesics) 0 (Anesthetics, Inhalation) 55JG375S6M (Pregabalin) CYS9AKD70P (Isoflurane) |
| تواريخ الأحداث: | Date Created: 20190919 Date Completed: 20201204 Latest Revision: 20201214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.23736/S0375-9393.19.13734-0 |
| PMID: | 31527572 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1827-1596 |
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| DOI: | 10.23736/S0375-9393.19.13734-0 |