دورية أكاديمية
أعرض في EDS

Dysbiotic microbiota in autistic children and their mothers: persistence of fungal and bacterial wall-deficient L-form variants in blood.

التفاصيل البيبلوغرافية
العنوان: Dysbiotic microbiota in autistic children and their mothers: persistence of fungal and bacterial wall-deficient L-form variants in blood.
المؤلفون: Markova N; Institute of Microbiology, Department of Infectious Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev str. 26, Sofia, 1113, Bulgaria. nadya.markova@gmail.com.
المصدر: Scientific reports [Sci Rep] 2019 Sep 16; Vol. 9 (1), pp. 13401. Date of Electronic Publication: 2019 Sep 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Autistic Disorder/*complications , Bacteria/*isolation & purification , Cell Wall/*microbiology , Dysbiosis/*pathology , Fungi/*isolation & purification , L Forms/*genetics , Mycoses/*pathology, Adult ; Bacteria/genetics ; Case-Control Studies ; Cell Wall/genetics ; Child ; Child, Preschool ; Dysbiosis/microbiology ; Female ; Fungi/genetics ; Humans ; Infectious Disease Transmission, Vertical ; L Forms/isolation & purification ; Male ; Microbiota ; Middle Aged ; Mycoses/microbiology
مستخلص: Based on our hypothesis for existing microbiota of wall-deficient variants (L-forms) in human blood, we created an innovative methodology, which allowed for the development of L-form populations from blood of all investigated people. In contrast to healthy controls, blood L-forms from autistic children and their mothers converted under appropriate conditions of cultivation into detectable opportunistic bacteria and fungi, а process demonstrated by light and transmission electron microscopy. It can be distinguished into two types of states - "eubiotic" blood microbiota in healthy individuals, and "dysbiotic" in autistic children and their mothers. Remarkably, the unifying finding for autistic children and their mothers was the presence in blood of wall-free variants from life-cycle of filamentous fungi. Increased specific IgG, IgM and IgA, together with typical mold growth were a decisive argument for proven presence of Aspergillus fumigatus in almost all of the autistic children. As it was demonstrated in our previous study, filterable L-forms can be transmitted by vertical pathway from mother to child before birth. Thus, it can be suggested that autistic children may be born already colonized with fungi, while a "silent aspergillosis" could contribute or even be a leading cause for neurodevelopmental disorders in the early childhood.
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تواريخ الأحداث: Date Created: 20190919 Date Completed: 20201106 Latest Revision: 20210110
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6746791
DOI: 10.1038/s41598-019-49768-9
PMID: 31527606
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-49768-9