دورية أكاديمية
Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors.
| العنوان: | Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors. |
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| المؤلفون: | Fuster V, Dewanjee MK, Kaye MP, Josa M, Metke MP, Chesebro JH |
| المصدر: | Circulation [Circulation] 1979 Dec; Vol. 60 (7), pp. 1508-12. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print Cited Medium: Print ISSN: 0009-7322 (Print) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Dallas, Tex., etc., American Heart Association, etc.] |
| مواضيع طبية MeSH: | Coronary Artery Bypass* , Indium* , Radioisotopes*, Aspirin/*pharmacology , Blood Platelets/*metabolism , Dipyridamole/*pharmacology, Animals ; Blood/metabolism ; Dogs ; Kidney/metabolism ; Liver/metabolism ; Lung/metabolism ; Muscles/metabolism ; Saphenous Vein/transplantation ; Spleen/metabolism |
| مستخلص: | At 8 and 32 hours after saphenous vein bypass graft surgery in six dogs, in vivo images of the graft were obtained with a gamma camera after intravenous injection, 2 hours postoperatively of autologous platelets labeled with indium-111. Platelet deposition in the grafts could be imaged in vivo from the scintiphotos. In vitro images of the excised heart showed saphenous vein graft uptake confirming the in vivo image. In vitro determination of radioactivity in the graft averaged 17 +/- 14 times greater than in blood and 33 +/- 26 times greater than in the lung. Under identical conditions, in eight dogs treated with dipyridamole (55 mg/day) plus aspirin (325 mg/day), the grafts appeared to have considerably less platelet deposition as estimated by imaging. In vitro determination of radioactivity in the graft averaged 5 +/- 2 times greater than in blood and 8 +/- 4 times greater than in the lung (p less than 0.01). This noninvasive technique may be a promising tool for a better understanding of the role played by platelets in the process of occlusion of saphenous vein bypass grafts in man and its prevention with platelet inhibotors. |
| المشرفين على المادة: | 0 (Radioisotopes) 045A6V3VFX (Indium) 64ALC7F90C (Dipyridamole) R16CO5Y76E (Aspirin) |
| تواريخ الأحداث: | Date Created: 19791201 Date Completed: 19800128 Latest Revision: 20190623 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1161/01.cir.60.7.1508 |
| PMID: | 315282 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0009-7322 |
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| DOI: | 10.1161/01.cir.60.7.1508 |