دورية أكاديمية
Prevalence and Factors Associated with Human Parvovirus B19 Infection in Sickle Cell Patients Hospitalized in Tanzania.
| العنوان: | Prevalence and Factors Associated with Human Parvovirus B19 Infection in Sickle Cell Patients Hospitalized in Tanzania. |
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| المؤلفون: | Urio F; Department of Biochemistry, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania., George H; Department of Biochemistry, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania., Tluway F; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania., Nyambo TB; Department of Biochemistry, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania., Mmbando BP; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.; National Institute for Medical Research, Tanga, Tanzania., Makani J; Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.; Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania. |
| المصدر: | Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2019 Sep 01; Vol. 11 (1), pp. e2019054. Date of Electronic Publication: 2019 Sep 01 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Università Cattolica del Sacro Cuore Country of Publication: Italy NLM ID: 101530512 Publication Model: eCollection Cited Medium: Print ISSN: 2035-3006 (Print) Linking ISSN: 20353006 NLM ISO Abbreviation: Mediterr J Hematol Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Roma, Italy : Università Cattolica del Sacro Cuore |
| مستخلص: | Background: The distribution of human parvovirus B19 (HPV B19) infection is ubiquitous and occurs worldwide. The virus has high tropism to red blood cells progenitor's cells leading to temporary infection of bone marrow and transient arrest of erythropoiesis. People with frequent episodes of hemolytic anemia including sickle cell disease (SCD) and thalassemia are at increased risk of infection. This study aimed at assessing prevalence and factors associated with HPV B19 infections among hospitalized SCD patients. Methodology: This was a cross-sectional hospital-based study among SCD patients hospitalized at Muhimbili National Hospital. HPV B19 was detected using RT-PCR. Hematological and Chemistry tests were done using Sysmex XT2000i and Chemistry analyzer respectively. Results: A total of 329 SCD patients, median age 15 years (interquartile range 7-22 years) were tested for HPV B19. The prevalence of HPV B19 was 29%. In multivariate logistic regression model, HPV B19 infection was associated with pain (OR=4.28, 95%CI: 1.20-15.19; p=0.025), low neutrophil counts (OR=0.57, 95%CI: 0.35-0.92, p=0.022) and MCH (OR=0.92, 95%CI: 0.85-0.99; p=0.033). Individuals infected with HPV B19 had slightly higher prevalence of severe anaemia (30.4% vs. 20.3%, p=0.054) and HIV infection (6.0% vs. 2.1%, p=0.083) in the univariate analysis. Considering the effect of HPV B19 virus on spleen, aplastic anemia and platelet counts in SCD patients, our study did not find any association with these parameters (p=0.244; p= 0.205 and p=0.567 respectively). Conclusion: The prevalence of HPV B19 among hospitalized SCD patients at MNH was high. SCD patients with HPV B19 were more likely to present with pain, low neutrophils levels, and MCH. HIV infection might be associated with a high risk of HPV infection in SCD patients; however, this requires further investigation. Competing Interests: Competing interests: The authors have declared that no competing interests exist. |
| التعليقات: | Comment in: Mediterr J Hematol Infect Dis. 2021 Mar 01;13(1):e2021026. (PMID: 33747407) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; U24 HL135881 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Human Parvovirus B19; RT-PCR; Sickle cell disease |
| تواريخ الأحداث: | Date Created: 20190919 Latest Revision: 20220410 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6736168 |
| DOI: | 10.4084/MJHID.2019.054 |
| PMID: | 31528320 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2035-3006 |
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| DOI: | 10.4084/MJHID.2019.054 |