دورية أكاديمية
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
| العنوان: | The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells. |
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| المؤلفون: | Araujo LP; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Maricato JT; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Guereschi MG; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Takenaka MC; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Nascimento VM; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., de Melo FM; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02458, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Brum PC; Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo 05508-030, Brazil., Basso AS; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil. Electronic address: asbasso@unifesp.br. |
| المصدر: | Cell reports [Cell Rep] 2019 Sep 17; Vol. 28 (12), pp. 3120-3130.e5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Immunity, Cellular*, Encephalomyelitis, Autoimmune, Experimental/*immunology , Multiple Sclerosis/*immunology , Receptors, Adrenergic, beta-2/*immunology , Signal Transduction/*immunology , Sympathetic Nervous System/*immunology , T-Lymphocytes/*immunology, Animals ; Cytokines/genetics ; Cytokines/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Mice ; Mice, Knockout ; Multiple Sclerosis/genetics ; Multiple Sclerosis/pathology ; Receptors, Adrenergic, beta-2/genetics ; Signal Transduction/genetics ; Sympathetic Nervous System/pathology ; T-Lymphocytes/pathology |
| مستخلص: | Noradrenaline (NE), the main neurotransmitter released by sympathetic nerve terminals, is known to modulate the immune response. However, the role of the sympathetic nervous system (SNS) on the development of autoimmune diseases is still unclear. Here, we report that the SNS limits the generation of pathogenic T cells and disease development in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). β2-Adrenergic receptor (Adrb2) signaling limits T cell autoimmunity in EAE through a mechanism mediated by the suppression of IL-2, IFN-γ, and GM-CSF production via inducible cAMP early repressor (ICER). Accordingly, the lack of Adrb2 signaling in immune cells is sufficient to abrogate the suppressive effects of SNS activity, resulting in increased pathogenic T cell responses and EAE development. Collectively, these results uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CD4(+) T cells; GM-CSF; ICER; IFN-γ; autoimmunity; experimental autoimmune encephalomyelitis; sympathetic nervous system; β2-adrenergic receptor |
| المشرفين على المادة: | 0 (ADRB2 protein, mouse) 0 (Cytokines) 0 (Receptors, Adrenergic, beta-2) |
| تواريخ الأحداث: | Date Created: 20190919 Date Completed: 20200910 Latest Revision: 20200910 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.celrep.2019.08.042 |
| PMID: | 31533035 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2019.08.042 |