دورية أكاديمية
أعرض في EDS

Altered Metabolomic Profile in Patients with Peripheral Artery Disease.

التفاصيل البيبلوغرافية
العنوان: Altered Metabolomic Profile in Patients with Peripheral Artery Disease.
المؤلفون: Ismaeel A; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA., Franco ME; Department of Environmental Science, Baylor University, Waco, TX 76798, USA., Lavado R; Department of Environmental Science, Baylor University, Waco, TX 76798, USA., Papoutsi E; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA., Casale GP; Department of Surgery, University of Nebraska at Medical Center, Omaha, NE 68198, USA., Fuglestad M; Department of Surgery, University of Nebraska at Medical Center, Omaha, NE 68198, USA., Mietus CJ; Department of Surgery, University of Nebraska at Medical Center, Omaha, NE 68198, USA., Haynatzki GR; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE 68198, USA., Smith RS; Department of Surgery, Baylor Scott and White Hospital, Temple, TX 76508, USA., Bohannon WT; Department of Surgery, Baylor Scott and White Hospital, Temple, TX 76508, USA., Sawicki I; Department of Surgery, Baylor Scott and White Hospital, Temple, TX 76508, USA., Pipinos II; Department of Surgery, University of Nebraska at Medical Center, Omaha, NE 68198, USA., Koutakis P; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA. pkoutakis@fsu.edu.
المصدر: Journal of clinical medicine [J Clin Med] 2019 Sep 14; Vol. 8 (9). Date of Electronic Publication: 2019 Sep 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients.
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معلومات مُعتمدة: N/A Charles and the Mary Heider Fund for Excellence in Vascular Surgery; 17SDG33630088 American Heart Association; AG049868 United States NH NIH HHS; R01 AG064420 United States AG NIA NIH HHS; AG034995 United States NH NIH HHS
فهرسة مساهمة: Keywords: claudication; critical limb ischemia (CLI); metabolomics; peripheral artery disease (PAD)
تواريخ الأحداث: Date Created: 20190922 Latest Revision: 20240720
رمز التحديث: 20240720
مُعرف محوري في PubMed: PMC6780416
DOI: 10.3390/jcm8091463
PMID: 31540015
قاعدة البيانات: MEDLINE
الوصف
تدمد:2077-0383
DOI:10.3390/jcm8091463