دورية أكاديمية
أعرض في EDS

Characteristics and clinical applications of Wharton's jelly-derived mesenchymal stromal cells.

التفاصيل البيبلوغرافية
العنوان: Characteristics and clinical applications of Wharton's jelly-derived mesenchymal stromal cells.
المؤلفون: Liau LL; Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia., Ruszymah BHI; Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia., Ng MH; Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia., Law JX; Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia. Electronic address: lawjx@ppukm.ukm.edu.my.
المصدر: Current research in translational medicine [Curr Res Transl Med] 2020 Jan; Vol. 68 (1), pp. 5-16. Date of Electronic Publication: 2019 Sep 19.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier-Masson SAS Country of Publication: France NLM ID: 101681234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-3186 (Electronic) Linking ISSN: 24523186 NLM ISO Abbreviation: Curr Res Transl Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Issy-les-Moulineaux Cedex] : Elsevier-Masson SAS, 2016-
مواضيع طبية MeSH: Mesenchymal Stem Cell Transplantation*, Mesenchymal Stem Cells/*cytology , Wharton Jelly/*cytology, Adult ; Adult Stem Cells/cytology ; Cell Lineage ; Cell Separation/methods ; Cells, Cultured ; Chronic Disease/therapy ; Clinical Trials as Topic ; Embryonic Stem Cells/cytology ; Graft Rejection/therapy ; Graft vs Host Disease/therapy ; Humans ; Immunosuppression Therapy ; Induced Pluripotent Stem Cells/cytology ; Infant, Newborn ; Organ Specificity ; Tissue Engineering/methods
مستخلص: Mesenchymal stromal cells (MSCs) are widely used in the clinic because they involve fewer ethical issues and safety concerns compared to other stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). MSCs derived from umbilical cord Wharton's jelly (WJ-MSCs) have excellent proliferative potential and a faster growth rate and can retain their multipotency for more passages in vitro compared to adult MSCs from bone marrow or adipose tissue. WJ-MSCs are used clinically for repairing tissue injuries of the spinal cord, liver and heart with the aim of regenerating tissue. On the other hand, WJ-MSCs are also used clinically to ameliorate immune-mediated diseases based on their ability to modulate immune responses. In the field of tissue engineering, WJ-MSCs capable of differentiating into multiple cell lineages have been used to produce a variety of engineered tissues in vitro that can then be transplanted in vivo. This review discusses the characteristics of WJ-MSCs, the differences between WJ-MSCs and adult MSCs, clinical studies involving WJ-MSCs and future perspectives of WJ-MSC research and clinical applications. To summarize, WJ-MSCs have shown promise in treating a variety of diseases clinically. However, most clinical trials/studies reported thus far are relatively smaller in scale. The collected evidence is insufficient to support the routine use of WJ-MSC therapy in the clinic. Thus, rigorous clinical trials are needed in the future to obtain more information on WJ-MSC therapy safety and efficacy.
(Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Cell therapy; Clinical; Mesenchymal stromal cells; Umbilical cord; Wharton’s jelly
تواريخ الأحداث: Date Created: 20190924 Date Completed: 20210819 Latest Revision: 20211204
رمز التحديث: 20240628
DOI: 10.1016/j.retram.2019.09.001
PMID: 31543433
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-3186
DOI:10.1016/j.retram.2019.09.001