دورية أكاديمية
أعرض في EDS

Sex Differences in Presentation but Not in Outcome for ACTH-Dependent Cushing's Syndrome.

التفاصيل البيبلوغرافية
العنوان: Sex Differences in Presentation but Not in Outcome for ACTH-Dependent Cushing's Syndrome.
المؤلفون: Broersen LHA; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, Netherlands.; Department of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., van Haalen FM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, Netherlands., Kienitz T; Department of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Biermasz NR; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, Netherlands., Strasburger CJ; Department of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Dekkers OM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands., Pereira AM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, Netherlands.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2019 Aug 30; Vol. 10, pp. 580. Date of Electronic Publication: 2019 Aug 30 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: Background: Sex differences in clinical picture of ACTH-dependent Cushing's syndrome are controversial, except for the known higher prevalence in females. We compared a broad range of potential differences to enable a more accurate understanding of the clinical picture of sex-specific ACTH-dependent Cushing's syndrome. Methods: Cohort study including consecutive patients with ACTH-dependent Cushing's syndrome from Leiden and Berlin diagnosed between 2000 and 2016. We compared clinical presentation, biochemical parameters, diagnostic tests, surgical outcome, and comorbidities between men and women. Results: We included 130 patients: 37 males and 93 females. With similar cortisol concentrations, ACTH concentrations were higher in males than females at time of diagnosis (median: 116 vs. 57 ng/L). The prevalence of osteoporosis was higher in males than in females (48.6 vs. 25.0%), persisting after surgery, with more vertebral fractures (16.2 vs. 5.4%) before surgery. Males showed more anemia (75.9 vs. 36.8%) after surgery. There were no differences in etiology, pituitary tumor size, diagnostic and therapeutic strategy, or surgical outcome between sexes. Conclusions: Based on this study, males and females with ACTH-dependent Cushing's syndrome present different clinical patterns. However, these differences do not justify different diagnostic strategies or treatment based on sex, considering the similar surgical outcome. Clinicians should be alert to diagnose accompanying osteoporosis (with fractures) in male patients with ACTH-dependent Cushing's syndrome.
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فهرسة مساهمة: Keywords: Cushing's disease; clinical outcome; clinical picture; ectopic Cushing's syndrome; sex differences
تواريخ الأحداث: Date Created: 20190924 Latest Revision: 20200225
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6730597
DOI: 10.3389/fendo.2019.00580
PMID: 31543864
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2019.00580