التفاصيل البيبلوغرافية
| العنوان: |
Clonidine improves memory function in schizophrenia independently from change in psychosis. Preliminary findings. |
| المؤلفون: |
Fields RB; Veterans Administration Medical Center, Pittsburgh, PA 15206., Van Kammen DP, Peters JL, Rosen J, Van Kammen WB, Nugent A, Stipetic M, Linnoila M |
| المصدر: |
Schizophrenia research [Schizophr Res] 1988 Nov-Dec; Vol. 1 (6), pp. 417-23. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print Cited Medium: Print ISSN: 0920-9964 (Print) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: |
Clonidine/*therapeutic use , Memory Disorders/*drug therapy , Schizophrenia/*complications, Adult ; Humans ; Male ; Memory Disorders/etiology ; Middle Aged ; Schizophrenia/drug therapy |
| مستخلص: |
This study provides initial evidence that the alpha 2-adrenergic receptor agonist, clonidine, enhances memory functioning in hospitalized schizophrenics. Ten patients were tested while drug free and while on stable doses of clonidine (0.4-1.4 mg/day) for approximately 3 weeks. Throughout the duration of the study, all patients, as well as the examiner, were blind to medication status. Memory test scores were significantly better during the clonidine trials. This improvement occurred independently of change in psychosis. Clonidine does not improve memory in normal adults or in young and unimpaired animals, but has been shown to improve memory in Korsakoff's patients and non-human primates who are old or have dorsolateral prefrontal cortical lesions. The present results have implications for the role of the noradrenergic system in memory as well as for our understanding of the nature of the cognitive deficits associated with schizophrenia. |
| المشرفين على المادة: |
MN3L5RMN02 (Clonidine) |
| تواريخ الأحداث: |
Date Created: 19881101 Date Completed: 19910405 Latest Revision: 20190912 |
| رمز التحديث: |
20221213 |
| DOI: |
10.1016/0920-9964(88)90024-2 |
| PMID: |
3154529 |
| قاعدة البيانات: |
MEDLINE |
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