دورية أكاديمية
Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali.
العنوان: | Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali. |
---|---|
المؤلفون: | Zambrana LE; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., McKeen S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Ibrahim H; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Zarei I; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Borresen EC; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Doumbia L; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Boré A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Cissoko A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Douyon S; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Koné K; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Perez J; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., Perez C; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., Hess A; Department of Statistics, Colorado State University, Fort Collins, CO, 80523, USA., Abdo Z; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80521, USA., Sangaré L; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Maiga A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Becker-Dreps S; Departments of Family Medicine and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7595, USA., Yuan L; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Koita O; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali. okoita@icermali.org., Vilchez S; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua. samuelvilchez@gmail.com., Ryan EP; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA. E.P.Ryan@colostate.edu. |
المصدر: | Scientific reports [Sci Rep] 2019 Sep 26; Vol. 9 (1), pp. 13919. Date of Electronic Publication: 2019 Sep 26. |
نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Body Weight* , Gastrointestinal Microbiome* , Metabolome* , Weaning*, Dietary Supplements/*adverse effects , Whole Grains/*adverse effects, Body Size ; Child Development ; Female ; Humans ; Infant ; Male ; Mali ; Nicaragua ; Oryza/adverse effects |
مستخلص: | Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1-5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6-8 and 8-12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent. |
References: | Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5. (PMID: 20566857) EBioMedicine. 2017 Mar;17:57-66. (PMID: 28122695) PLoS Negl Trop Dis. 2018 Jan 19;12(1):e0006205. (PMID: 29351288) Sci Rep. 2017 Jan 12;7:40466. (PMID: 28079170) Cell Host Microbe. 2015 May 13;17(5):681-9. (PMID: 25891358) BMC Microbiol. 2012 Jul 04;12:71. (PMID: 22583915) Sci Rep. 2018 Jan 23;8(1):1395. (PMID: 29362450) Appl Environ Microbiol. 2013 Sep;79(17):5112-20. (PMID: 23793624) Environ Microbiol. 2016 May;18(5):1403-14. (PMID: 26271760) Ann Nutr Metab. 2012;61 Suppl 1:19-27. (PMID: 23343944) EBioMedicine. 2015 Sep 25;2(11):1759-66. (PMID: 26870801) N Engl J Med. 2018 Apr 26;378(17):1583-1592. (PMID: 29694816) Bioresour Technol. 2004 Apr;92(2):157-61. (PMID: 14693448) N Engl J Med. 2010 Jan 28;362(4):289-98. (PMID: 20107214) Am J Clin Nutr. 1999 Apr;69(4):679-86. (PMID: 10197569) Appl Physiol Nutr Metab. 2016 Jun;41(6):581-7. (PMID: 27177124) Rice (N Y). 2017 Dec;10(1):24. (PMID: 28547736) J Nutr. 2017 Jan;147(1):97-103. (PMID: 27807040) Metabolites. 2018 Oct 09;8(4):. (PMID: 30304872) Food Nutr Bull. 2014 Jun;35(2 Suppl):S64-70. (PMID: 25069296) Appl Environ Microbiol. 2009 Dec;75(23):7537-41. (PMID: 19801464) Curr Protein Pept Sci. 2017;18(8):795-808. (PMID: 28215168) Gut Pathog. 2016 Nov 8;8:51. (PMID: 27826359) Front Microbiol. 2017 Jun 23;8:1162. (PMID: 28690602) Clin Vaccine Immunol. 2014 Oct;21(10):1396-403. (PMID: 25080551) Cell Mol Gastroenterol Hepatol. 2015 Dec 11;2(2):158-174.e1. (PMID: 26973864) Lancet. 1991 Oct 12;338(8772):907-10. (PMID: 1681266) J Nutr. 2014 Dec;144(12):2059-65. (PMID: 25411039) Nutrients. 2016 Sep 15;8(9):. (PMID: 27649240) ISME J. 2012 Aug;6(8):1621-4. (PMID: 22402401) Lancet Glob Health. 2015 Nov;3(11):e701-11. (PMID: 26475017) Front Cell Infect Microbiol. 2012 Jun 22;2:86. (PMID: 22919677) Pediatrics. 2010 Mar;125(3):e473-80. (PMID: 20156903) Lancet. 2008 Jan 19;371(9608):243-60. (PMID: 18207566) Clin Infect Dis. 2014 Nov 1;59 Suppl 4:S207-12. (PMID: 25305288) Am J Trop Med Hyg. 2015 Jun;92(6):1117-24. (PMID: 25918214) Front Nutr. 2018 Jan 19;4:71. (PMID: 29404331) Nature. 2012 May 09;486(7402):222-7. (PMID: 22699611) Am J Pathol. 2018 May;188(5):1183-1194. (PMID: 29454749) Antimicrob Agents Chemother. 2013 May;57(5):2016-25. (PMID: 23403424) Cell Rep. 2018 Jun 5;23(10):3056-3067. (PMID: 29874590) Nat Commun. 2015 Aug 04;6:7806. (PMID: 26241678) Genome Biol. 2015 Sep 15;16:191. (PMID: 26374288) J Nutr. 2003 May;133(5):1332-8. (PMID: 12730419) J Pediatr Gastroenterol Nutr. 2004 Aug;39(2):153-7. (PMID: 15269619) Sci Rep. 2016 Feb 26;6:21618. (PMID: 26916743) Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22. (PMID: 20534432) J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):6-14. (PMID: 26974416) Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283) Trends Mol Med. 2012 Jun;18(6):328-36. (PMID: 22633998) Nature. 2014 Jun 19;510(7505):417-21. (PMID: 24896187) Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G1-9. (PMID: 22016433) Sci Transl Med. 2016 Jun 15;8(343):343ra82. (PMID: 27306664) Immunol Rev. 2017 Sep;279(1):70-89. (PMID: 28856738) Cell Host Microbe. 2015 Jun 10;17(6):852. (PMID: 26308884) Nat Methods. 2013 Dec;10(12):1200-2. (PMID: 24076764) Food Nutr Bull. 2013 Sep;34(3):357-64. (PMID: 24167916) BMC Med. 2014 Oct 14;12:187. (PMID: 25604120) Am J Trop Med Hyg. 2013 Feb;88(2):390-396. (PMID: 23185075) mSystems. 2015 Dec 22;1(1):. (PMID: 27822518) Front Cell Infect Microbiol. 2018 Feb 06;8:13. (PMID: 29468141) PLoS One. 2016 Sep 30;11(9):e0158772. (PMID: 27690129) Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4578-85. (PMID: 20668239) Nature. 2011 Jun 15;474(7351):327-36. (PMID: 21677749) J Med Food. 2012 May;15(5):469-75. (PMID: 22248178) Am J Trop Med Hyg. 2017 Feb 8;96(2):465-472. (PMID: 27994110) Inflamm Bowel Dis. 2016 Feb;22(2):487-504. (PMID: 26588090) Front Microbiol. 2016 Nov 02;7:1699. (PMID: 27853451) PLoS Negl Trop Dis. 2014 Dec 11;8(12):e3369. (PMID: 25503381) ISME J. 2016 Jan;10(1):145-57. (PMID: 26066712) Front Microbiol. 2018 Jun 27;9:1376. (PMID: 29997594) Nutrients. 2015 Feb 16;7(2):1282-300. (PMID: 25690418) Sci Rep. 2015 Oct 13;5:15004. (PMID: 26459937) Br J Nutr. 2017 May;117(9):1244-1256. (PMID: 28643618) Am J Clin Nutr. 2016 Nov;104(5):1253-1262. (PMID: 27733402) Ann N Y Acad Sci. 2014 Sep;1324:7-14. (PMID: 25224455) Gut Microbes. 2017 Mar 4;8(2):98-112. (PMID: 27918230) Pediatr Infect Dis J. 2017 Apr;36(4):412-416. (PMID: 27977553) Front Microbiol. 2017 Apr 21;8:653. (PMID: 28484432) Glob Pediatr Health. 2017 Feb 16;4:2333794X17694231. (PMID: 28345013) Clin Transl Immunology. 2017 Feb 10;6(2):e128. (PMID: 28243438) Am J Trop Med Hyg. 2017 Feb 8;96(2):473-476. (PMID: 27956653) |
تواريخ الأحداث: | Date Created: 20190928 Date Completed: 20201027 Latest Revision: 20210110 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6763478 |
DOI: | 10.1038/s41598-019-50344-4 |
PMID: | 31558739 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
---|---|
DOI: | 10.1038/s41598-019-50344-4 |