دورية أكاديمية
أعرض في EDS

Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali.

التفاصيل البيبلوغرافية
العنوان: Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali.
المؤلفون: Zambrana LE; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., McKeen S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Ibrahim H; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Zarei I; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Borresen EC; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Doumbia L; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Boré A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Cissoko A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Douyon S; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Koné K; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Perez J; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., Perez C; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua., Hess A; Department of Statistics, Colorado State University, Fort Collins, CO, 80523, USA., Abdo Z; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80521, USA., Sangaré L; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Maiga A; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali., Becker-Dreps S; Departments of Family Medicine and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7595, USA., Yuan L; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Koita O; Laboratoire de Biologie Moléculaire Appliquée, Campus de Badalabougou, Université des Sciences, des Techniques et des Technologies de Bamako, BP: 1805, Bamako, Mali. okoita@icermali.org., Vilchez S; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua. samuelvilchez@gmail.com., Ryan EP; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA. E.P.Ryan@colostate.edu.
المصدر: Scientific reports [Sci Rep] 2019 Sep 26; Vol. 9 (1), pp. 13919. Date of Electronic Publication: 2019 Sep 26.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Body Weight* , Gastrointestinal Microbiome* , Metabolome* , Weaning*, Dietary Supplements/*adverse effects , Whole Grains/*adverse effects, Body Size ; Child Development ; Female ; Humans ; Infant ; Male ; Mali ; Nicaragua ; Oryza/adverse effects
مستخلص: Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1-5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6-8 and 8-12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent.
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تواريخ الأحداث: Date Created: 20190928 Date Completed: 20201027 Latest Revision: 20210110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6763478
DOI: 10.1038/s41598-019-50344-4
PMID: 31558739
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-50344-4