دورية أكاديمية
A Multicenter Japanese Survey Assessing the Long-term Outcomes of Liver Retransplantation Using Living Donor Grafts.
| العنوان: | A Multicenter Japanese Survey Assessing the Long-term Outcomes of Liver Retransplantation Using Living Donor Grafts. |
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| المؤلفون: | Kuramitsu K; Department of Surgery, Division of Hepato-Biliary and Pancreatic Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan., Fukumoto T; Department of Surgery, Division of Hepato-Biliary and Pancreatic Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan., Egawa H; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan., Ohdan H; Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Umeshita K; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan., Uemoto S; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Hibi T; Department of Pediatric Surgery and Transplantation, Kumamoto University Hospital, Kumamoto, Japan., Kasahara M; Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan., Yoshizumi T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Mizuta K; Department of Transplant Surgery, Jichi Medical University, Tochigi, Japan., Shimamura T; Division of Organ Transplantation, Central Clinical Facilities, Hokkaido University Hospital, Hokkaido, Japan., Furukawa H; Department of Surgery, Asahikawa Medical University, Hokkaido, Japan. |
| المصدر: | Transplantation [Transplantation] 2020 Apr; Vol. 104 (4), pp. 754-761. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Liver Transplantation*/adverse effects , Liver Transplantation*/mortality , Living Donors*, Graft Rejection/*surgery , Liver Diseases/*surgery, Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Donor Selection ; Female ; Graft Rejection/diagnosis ; Graft Rejection/mortality ; Graft Survival ; Health Care Surveys ; Humans ; Infant ; Infant, Newborn ; Japan ; Liver Diseases/diagnosis ; Liver Diseases/mortality ; Male ; Middle Aged ; Recurrence ; Reoperation ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Young Adult |
| مستخلص: | Background: Liver transplantation is the most suitable treatment option available for end-stage liver disease. However, some patients require retransplantation, despite medical advances that have led to improved survival. We aimed to compile a definitive, nationwide resource of liver retransplantation data in Japan, seeking to identify the predictors of patient survival posttransplantation. Methods: Questionnaires were sent to 32 institutions that had conducted 281 retransplantations before 2015. Results: Among the 265 patients included in this study (142 pediatric cases), the average age at primary transplantation was 23 years, and retransplantation was performed after an average of 1468 days. The main indication for retransplantation was graft rejection (95 patients). Living-donor liver transplantation accounted for 94.7% of primary transplantations and 73.2% of retransplantations. Patient survival at 1, 3, or 5 years did not differ by type of transplantation but was better for pediatric (70.8%, 68.3%, and 60.1%, respectively) than for adult (57.2%, 50.4%, and 45.2%, respectively) recipients (P = 0.0003). Small-for-size syndrome, retransplantation within 365 days, and inpatient status at retransplantation were significant predictors of poor survival in pediatric cases. Retransplantation within 365 days and conditions warranting retransplantation were significant predictors of poor survival in adult patients. Conclusions: In Japan, where >70% of retransplantations are performed using living donors, the indications and timing are different from those in previous reports from other countries, while maintaining comparable survival rates. Considering technical challenges, graft failure within 365 days should be thoroughly restricted to justify the use of living donor. |
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| تواريخ الأحداث: | Date Created: 20191001 Date Completed: 20201007 Latest Revision: 20210125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/TP.0000000000002958 |
| PMID: | 31568214 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1534-6080 |
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| DOI: | 10.1097/TP.0000000000002958 |