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Cooking shapes the structure and function of the gut microbiome.

التفاصيل البيبلوغرافية
العنوان: Cooking shapes the structure and function of the gut microbiome.
المؤلفون: Carmody RN; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA. carmody@fas.harvard.edu.; Center for Systems Biology, Harvard University, Cambridge, MA, USA. carmody@fas.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. carmody@fas.harvard.edu., Bisanz JE; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Bowen BP; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Maurice CF; Center for Systems Biology, Harvard University, Cambridge, MA, USA.; Department of Microbiology & Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada., Lyalina S; Gladstone Institutes, University of California San Francisco, San Francisco, CA, USA., Louie KB; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Treen D; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Chadaideh KS; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA., Maini Rekdal V; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Bess EN; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Spanogiannopoulos P; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Ang QY; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Bauer KC; Center for Systems Biology, Harvard University, Cambridge, MA, USA., Balon TW; Department of Medicine, Metabolic Phenotyping Core and In Vivo Imaging System Core, Boston University, Boston, MA, USA., Pollard KS; Gladstone Institutes, University of California San Francisco, San Francisco, CA, USA., Northen TR; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Turnbaugh PJ; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA. peter.turnbaugh@ucsf.edu.; Center for Systems Biology, Harvard University, Cambridge, MA, USA. peter.turnbaugh@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. peter.turnbaugh@ucsf.edu.
المصدر: Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2052-2063. Date of Electronic Publication: 2019 Sep 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Publishing Group, [2016]-
مواضيع طبية MeSH: Cooking* , Diet* , Food* , Gastrointestinal Microbiome*, Bacteria/*classification , Raw Foods/*analysis, Adult ; Animals ; Feces/microbiology ; Female ; Genetic Variation ; Germ-Free Life ; Hot Temperature ; Humans ; Male ; Metabolomics ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; RNA, Ribosomal, 16S/genetics ; Transcriptome ; Young Adult
مستخلص: Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics 1-3 . Numerous microbiome studies have compared diets with divergent ingredients 1-5 , but the everyday practice of cooking remains understudied. Here, we show that a plant diet served raw versus cooked reshapes the murine gut microbiome, with effects attributable to improvements in starch digestibility and degradation of plant-derived compounds. Shifts in the gut microbiota modulated host energy status, applied across multiple starch-rich plants, and were detectable in humans. Thus, diet-driven host-microbial interactions depend on the food as well as its form. Because cooking is human-specific, ubiquitous and ancient 6,7 , our results prompt the hypothesis that humans and our microbiomes co-evolved under unique cooking-related pressures.
التعليقات: Comment in: Nat Rev Microbiol. 2019 Dec;17(12):721. (PMID: 31624359)
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معلومات مُعتمدة: F32 DK101154 United States DK NIDDK NIH HHS; R01 HL122593 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20191002 Date Completed: 20200707 Latest Revision: 20220417
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6886678
DOI: 10.1038/s41564-019-0569-4
PMID: 31570867
قاعدة البيانات: MEDLINE
الوصف
تدمد:2058-5276
DOI:10.1038/s41564-019-0569-4