دورية أكاديمية
أعرض في EDS

Preliminary results of a counselling programme for fertility preservation in female cancer patients: The experience of the GEMME DORMIENTI network.

التفاصيل البيبلوغرافية
العنوان: Preliminary results of a counselling programme for fertility preservation in female cancer patients: The experience of the GEMME DORMIENTI network.
المؤلفون: Ciccarone M; Department of Gynaecology, San Carlo di Nancy Hospital, Rome, Italy.; Gemme Dormienti Association ONLUS, Rome, Italy., Hohaus S; Policlinico Gemelli Foundation, Catholic University of the Sacred Heart, Rome, Italy., Pulsoni A; Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy., Cavaceppi P; LabAurelia, Rome, Italy., Franzò S; Gemme Dormienti Association ONLUS, Rome, Italy., Fabbri R; Gynaecology and Physiopathology of Human Reproduction Unit, Department of Medical and Surgical Sciences, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy., Cudillo L; Haematology and Stem Cell Transplant Unit, Tor Vergata University, Roma, Italy., Battistini R; A.O. San Camillo Forlanini U.O.C. Ematologia e Trapianti CSE, Rome, Italy., Di Rocco A; Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy., Annibali O; UOC Haematology Stem Cell Transplantation, University Campus Bio Medico, Rome, Italy., Cox MC; Haematology Unit, Azienda Ospedaliera-Universitaria Sant'Andrea, Rome, Italy., Provenzano I; UOC Oncoematologia Fondazione Policlinico Tor Vergata, Rome, Italy., Abruzzese E; Ematologia Ospedale S. Eugenio Università Tor Vergata, Rome, Italy., Renzi D; Haematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Tesei C; Gemme Dormienti Association ONLUS, Rome, Italy., Anticoli Borza P; UOC Ematologia- Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy., Cuccaro A; Policlinico Gemelli Foundation, Catholic University of the Sacred Heart, Rome, Italy., Andriani A; UOSD di Ematologia, Rome, Italy.; UOC di Ematologia, Osp. F. Spaziani, ASL Frosinone, Rome, Italy., D'Elia GM; Department of Cellular Biotechnology and Haematology, Sapienza University, Rome, Italy., Facchiano A; Department of Medical Oncology Sant' Andrea Hospital, Rome, Italy., Marchetti P; Department of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome, Italy., Cantonetti M; UOC Oncoematologia Fondazione Policlinico Tor Vergata, Rome, Italy.
المصدر: European journal of cancer care [Eur J Cancer Care (Engl)] 2020 Jan; Vol. 29 (1), pp. e13174. Date of Electronic Publication: 2019 Sep 30.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 9301979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2354 (Electronic) Linking ISSN: 09615423 NLM ISO Abbreviation: Eur J Cancer Care (Engl)
أسماء مطبوعة: Publication: <1992- > : Oxford : Wiley
Original Publication: London : [Marston Book Services], 1991-
مواضيع طبية MeSH: Antineoplastic Agents/*adverse effects , Fertility Preservation/*methods , Gonadotropin-Releasing Hormone/*agonists , Infertility, Female/*prevention & control , Primary Ovarian Insufficiency/*prevention & control, Adolescent ; Adult ; Anti-Mullerian Hormone/blood ; Counseling ; Cryopreservation ; Estradiol/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Infertility, Female/chemically induced ; Longitudinal Studies ; Luteinizing Hormone/blood ; Oocyte Retrieval ; Oocytes ; Ovarian Follicle ; Ovarian Reserve ; Ovary ; Ovulation Induction ; Patient Preference ; Primary Ovarian Insufficiency/chemically induced ; Progesterone/blood ; Referral and Consultation ; Young Adult
مستخلص: Objective: To describe a population of patients referred for fertility preservation (FP), how to efficiently provide FP care, and how FP care changed over time.
Methods: This longitudinal observational study enrolled 281 female cancer patients referred between 2013 and 2016 to the non-profit organisation Gemme Dormienti ONLUS (GD) for FP care. All patients underwent the same battery of instrumental and laboratory diagnostic tests. GnRHa therapy was started at least seven days before CTh treatment.
Results: From 2013 to 2016, we observed a progressive increase in the number of patients referred for FP care. Out of 251 eligible patients, 135 patients were treated with GnRHa only, and 72 patients underwent GnRHa therapy and cryopreservation. The median time from GD referral to oocyte and ovarian tissue cryopreservation was 11 and 5 days respectively. Tissue cryopreservation requests increased during our study period (from four cases in 2013 to 17 cases in 2016). During follow-up, 17β-estradiol and FSH levels were significantly increased (p < .0001), and AMH levels were significantly decreased (p < .0001).
Conclusion: The rapid increase in the number of patients who requested FP care and in the complexity of FP procedures overtime reflects the need to improve quality of life for cancer patients.
(© 2019 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: OPM (Otto Per Mille) Chiesa Evangelica Valdese
فهرسة مساهمة: Keywords: GnRHa; cancer; counselling; fertility preservation; oocyte cryopreservation; ovarian tissue cryopreservation
المشرفين على المادة: 0 (Antineoplastic Agents)
33515-09-2 (Gonadotropin-Releasing Hormone)
4G7DS2Q64Y (Progesterone)
4TI98Z838E (Estradiol)
80497-65-0 (Anti-Mullerian Hormone)
9002-67-9 (Luteinizing Hormone)
9002-68-0 (Follicle Stimulating Hormone)
تواريخ الأحداث: Date Created: 20191002 Date Completed: 20201116 Latest Revision: 20201116
رمز التحديث: 20240628
DOI: 10.1111/ecc.13174
PMID: 31571303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2354
DOI:10.1111/ecc.13174