دورية أكاديمية
أعرض في EDS

Allele-specific nonstationarity in evolution of influenza A virus surface proteins.

التفاصيل البيبلوغرافية
العنوان: Allele-specific nonstationarity in evolution of influenza A virus surface proteins.
المؤلفون: Popova AV; Department of Molecular Diagnostics, Central Research Institute for Epidemiology, Moscow, 111123 Russia., Safina KR; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, 143028 Russia.; Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences, Moscow, 127051 Russia., Ptushenko VV; A. N. Belozersky Institute of Physical-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, 119992 Russia.; Department of Photochemistry and Photobiology, N. M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, 119334 Russia., Stolyarova AV; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, 143028 Russia., Favorov AV; Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205.; Laboratory of System Biology and Computational Genetics, Vavilov Institute of General Genetics, Moscow, 119991 Russia., Neverov AD; Department of Molecular Diagnostics, Central Research Institute for Epidemiology, Moscow, 111123 Russia., Bazykin GA; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, 143028 Russia; g.bazykin@skoltech.ru.; Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences, Moscow, 127051 Russia.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Oct 15; Vol. 116 (42), pp. 21104-21112. Date of Electronic Publication: 2019 Oct 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Amino Acids/*genetics , Influenza A virus/*genetics , Membrane Proteins/*genetics , Viral Proteins/*genetics, Alleles ; Amino Acids/immunology ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Evolution, Molecular ; Genetic Variation/genetics ; Genetic Variation/immunology ; Influenza A virus/immunology ; Membrane Proteins/immunology ; Pandemics ; Viral Proteins/immunology
مستخلص: Influenza A virus (IAV) is a major public health problem and a pandemic threat. Its evolution is largely driven by diversifying positive selection so that relative fitness of different amino acid variants changes with time due to changes in herd immunity or genomic context, and novel amino acid variants attain fitness advantage. Here, we hypothesize that diversifying selection also has another manifestation: the fitness associated with a particular amino acid variant should decline with time since its origin, as the herd immunity adapts to it. By tracing the evolution of antigenic sites at IAV surface proteins, we show that an amino acid variant becomes progressively more likely to become replaced by another variant with time since its origin-a phenomenon we call "senescence." Senescence is particularly pronounced at experimentally validated antigenic sites, implying that it is largely driven by host immunity. By contrast, at internal sites, existing variants become more favorable with time, probably due to arising contingent mutations at other epistatically interacting sites. Our findings reveal a previously undescribed facet of adaptive evolution and suggest approaches for prediction of evolutionary dynamics of pathogens.
Competing Interests: The authors declare no competing interest.
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معلومات مُعتمدة: P30 CA006973 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: influenza; nonstationary evolution; selection
المشرفين على المادة: 0 (Amino Acids)
0 (Antigens, Viral)
0 (Membrane Proteins)
0 (Viral Proteins)
تواريخ الأحداث: Date Created: 20191004 Date Completed: 20200327 Latest Revision: 20200403
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6800338
DOI: 10.1073/pnas.1904246116
PMID: 31578251
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.1904246116