دورية أكاديمية
أعرض في EDS

Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.

التفاصيل البيبلوغرافية
العنوان: Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.
المؤلفون: Zaw AM; School of Biological Sciences, The University of Hong Kong, Hong Kong, China., Sekar R; School of Biological Sciences, The University of Hong Kong, Hong Kong, China., Mak SOK; School of Biological Sciences, The University of Hong Kong, Hong Kong, China., Law HKW; Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China. helen.law@polyu.edu.hk., Chow BKC; School of Biological Sciences, The University of Hong Kong, Hong Kong, China. bkcc@hku.hk.
المصدر: Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14211. Date of Electronic Publication: 2019 Oct 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Blood Pressure/*physiology , Hypertension/*physiopathology , Hypertension, Pulmonary/*physiopathology , Lung/*pathology , Myocardium/*pathology , Secretin/*deficiency, Airway Remodeling ; Aldosterone/analysis ; Angiotensin II/blood ; Animals ; Hemodynamics ; Hypertension/blood ; Hypertension/genetics ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/genetics ; Lung/chemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardium/chemistry ; Nitric Oxide/blood ; Renin/blood ; Secretin/genetics ; Telemetry ; Vascular Endothelial Growth Factor A/analysis ; Vasopressins/blood
مستخلص: More than 1 billion people globally are suffering from hypertension, which is a long-term incurable medical condition that can further lead to dangerous complications and death if left untreated. In earlier studies, the brain-gut peptide secretin (SCT) was found to be able to control blood pressure by its cardiovascular and pulmonary effects. For example, serum SCT in patients with congestive heart failure was one-third of the normal level. These observations strongly suggest that SCT has a causal role in blood pressure control, and in this report, we used constitutive SCT knockout (SCT -/- ) mice and control C57BL/6N mice to investigate differences in the morphology, function, underlying mechanisms and response to SCT treatment. We found that SCT -/- mice suffer from systemic and pulmonary hypertension with increased fibrosis in the lungs and heart. Small airway remodelling and pulmonary inflammation were also found in SCT -/- mice. Serum NO and VEGF levels were reduced and plasma aldosterone levels were increased in SCT -/- mice. Elevated cardiac aldosterone and decreased VEGF in the lungs were observed in the SCT -/- mice. More interestingly, SCT replacement in SCT -/- mice could prevent the development of heart and lung pathologies compared to the untreated group. Taken together, we comprehensively demonstrated the critical role of SCT in the cardiovascular and pulmonary systems and provide new insight into the potential role of SCT in the pathological development of cardiopulmonary and cardiovascular diseases.
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المشرفين على المادة: 0 (Vascular Endothelial Growth Factor A)
0 (vascular endothelial growth factor A, mouse)
11000-17-2 (Vasopressins)
11128-99-7 (Angiotensin II)
1393-25-5 (Secretin)
31C4KY9ESH (Nitric Oxide)
4964P6T9RB (Aldosterone)
EC 3.4.23.15 (Renin)
تواريخ الأحداث: Date Created: 20191004 Date Completed: 20201109 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6775067
DOI: 10.1038/s41598-019-50634-x
PMID: 31578376
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-50634-x